+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Medroxyprogesterone and palliative care: new indication. No impact on quality of life

, : Medroxyprogesterone and palliative care: new indication. No impact on quality of life. Prescrire International 10(51): 3-4

(1) Oral medroxyprogesterone has been granted a new licence in France for the treatment of weight loss and loss of appetite in patients receiving palliative care for cancer. (2) The clinical file on medroxyprogesterone in this indication is limited. A large number of patients were excluded from the final assessments in the three published placebo-controlled trials. (3) Overall, these trials show that 12 weeks of treatment with medroxyprogesterone 300-1,000 mg a day orally is associated at best with median weight gain of 3 kg, or weight stabilisation, but with no effect on quality of life. (4) Although no cases of thrombosis were reported in the clinical trials, the risk of thrombosis cannot be ruled out in medroxyprogesterone therapy.


PMID: 11503858

Other references

Scarizza, P.M., 1952: Bonnevie Ulrich syndrome in newborn; pathogenetic theory of blebs. Il Lattante 23(5): 283-293

Niklas, Kj, 1980: Paleobiochemical techniques and their applications to paleobotany. Progress in phytochemistry(6): 143-181

Abe, T.; E.A., 1968: Studies on native farm animals in Asia. I. On blood groups and serum protein polymorphism of East Asian cattle. Blood samples were taken from 127 Chinese Yellows in Taiwan, and from 159 Korean, 383 Japanese Brown, 122 Japanese Black and 156 Japanese Shorthorn cattle. Data of another author on Mishima cattle were also included. Frequencies of genes controlli...

Muting, D., 1972: Ride to Pamir. zoological impressions from North Afghanistan. Entomologische Zeitschrift: 82 (5) 33-44

Ringenberg, R.; Botton, M.; Garcia, M.S.lveira; Nondillo, A., 2005: Compared biology in artificial diets and thermal requirements of Cryptoblabes gnidiella Biologia comparada e exigencias termicas de Cryptoblabes gnidiella em dieta artificial. This work was conducted to evaluate the development of Cryptoblabes gnidiella in artificial diets, and to know the thermal requirements of the species. Biology was studied under laboratory conditions (26 plus or minus 1deg. C, relative humity of 7...

Suzuki Fumio, 1987: Explosion seismic observations around Fuji River using quarry blasts at Toshima, southern Yamanashi; Part 1. Journal of the Faculty of Marine Science and Technology, Tokai University 24: 17-33

Leifer, D.; Waters, A., 1997: More nurses struck off. NlmCategory="UNASSIGNED">THE PROPORTION of nurses struck off for professional misconduct has risen dramatically over the last three years.

Sotgiu, M.; Ganau, R.; Carta, A.; Pinna, A.; Carbone, F.; Carta, A., 1992: Prediction of post-operative refraction in intraocular lens implants. Several studies have compared the accuracy of theoretical and linear regression formulas for calculation of the intraocular lens (IOL) power in predicting the postoperative refraction. The Authors reviewed the refractive data from 100 eyes that un...

Hancock, R.D.; Roberts, A.G.; Viola, R., 2008: A role for symplastic gating in the control of the potato tuber life cycle. The control of the potato tuber life cycle has been the subject of significant interest over many years. A number of different approaches have been adopted and data is available regarding hormonal, metabolic and gene expression changes that occur...

Arellano, C.J.; O'Connor, D.P.; Layne, C.; Kurz, M.J., 2009: The independent effect of added mass on the stability of the sagittal plane leg kinematics during steady-state human walking. This study investigated the independent effect of added mass on the stability of the leg kinematics during human walking. We reasoned that adding mass would influence the body's inertial state and thus challenge the ability of the leg to redi...