+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Nasal mucociliary transport: new evidence for a key role of ciliary beat frequency

, : Nasal mucociliary transport: new evidence for a key role of ciliary beat frequency. Laryngoscope 112(3): 570-573

Mucociliary transport is an important defense mechanism of the respiratory tract. Nonetheless, the factors determining mucociliary transport are only partially understood. Ciliary beat frequency is assumed to be one of the main parameters, although the experimental evidence remains inconclusive. Comparing influences on mucociliary transport to influences on ciliary beat frequency. The present study measures the effects on mucociliary transport of two ciliary beat frequency-inhibiting compounds (0.1% xylometazoline and 0.9% NaCl) and a ciliary beat frequency enhancer (0.1% salbutamol). The measurements were performed by a technetium-99m nebulizing scintigraphic method. The experiments were carried out in 15 healthy young volunteers. The 0.1% xylometazoline appeared to slow ciliary transport, although the decrease was not significant (P = .44). The 0.9% NaCl did reduce mucociliary transport significantly (P = .033). The 0.1% salbutamol resulted in a highly significant increase of mucociliary transport (P = .009). Xylometazoline brings about drastic changes in the nasal cavity, both anatomically and physiologically. Any comparison of mucociliary transport before and after using this vasoconstrictive agent must take this effect into account. The present study demonstrates a significant similarity in the effects of NaCl and salbutamol on ciliary beat frequency in vitro and on mucociliary transport in vivo. The evidence from our experiments suggests that ciliary beat frequency is a determining factor in the mucociliary transport rate in the nose.


PMID: 12148873

DOI: 10.1097/00005537-200203000-00029

Other references

Turkina, M.V.; Kulikova, A.L.; Koppel', L.A.; Akatova, L.Z.; Butenko, R.G., 1995: Actin and thermostable actin-binding proteins in wheat cell culture. Quantitative analysis of total actin and its filament and globular forms was carried out in Triticum aestivum cell culture. The total actin concentration almost did not change for a long period of the time of cultivation and essentially did not di...

Morse D.C.; Koeter H.B.W.M.; Van Prooijen A.E.S.; Brouwer A., 1992: Interference of polychlorinated biphenyls in thyroid hormone metabolism possible neurotoxic consequences in fetal and neonatal rats. Prenatal administration of 3,3,4,4,5,5-hexachlorobiphenyl (HCB) and 3,3,4,4-tetrachlorobiphenyl (TCB) resulted in decreased plasma thyroid hormones and altered thyroid hormone metabolism in brain homogenates of pregnant Wistar WU rats, their fetus...

Bauer, D.; Keller, J.; Alt, M.; Schubert, A.; Aufderhorst, U.Wilhelm.; Palapys, V.; Kasper, M.; Heilingloh, C.Silke.; Dittmer, U.; Laffer, Börn.; Eis-Hübinger, A.Maria.; Verjans, G.M.; Heiligenhaus, A.; Roggendorf, M.; Krawczyk, A., 2017: Antibody-based immunotherapy of aciclovir resistant ocular herpes simplex virus infections. The increasing incidence of aciclovir- (ACV) resistant strains in patients with ocular herpes simplex virus (HSV) infections is a major health problem in industrialized countries. In the present study, the humanized monoclonal antibody (mAb) hu2c...

Outwater, E.K.; Siegelman, E.S.; Wilson, K.M.; Mitchell, D.G., 1996: Benign and malignant gynecologic disease: clinical importance of fluid and peritoneal enhancement in the pelvis at MR imaging. PURPOSE: To correlate magnetic resonance (MR) imaging findings of pelvic fluid, peritoneal enhancement, and peritoneal nodules with the presence of benign or malignant pelvic disease. MATERIALS AND METHODS: Pelvic MR imaging findings in 87 women (...

Lipsky, S.R.; Landowne, R.A., 1960: Gas chromatography--biochemical applications. Annual Review of Biochemistry 29: 649-668

Aleksandrova, T.B.; Udel'nov, M.G.; Samonina, G.E., 1974: Cortical influences on cardiac reflexes under conditions of sensorimotor cortex stimulation by an electrical current of varying parameters. Nauchnye Doklady Vysshei Shkoly. Biologicheskie Nauki 1: 28-33

Desaymard, C.; Howard, J.G., 1975: Role of epitope density in the induction of immunity and tolerance with thymus-independent antigens. II. Studies with 2,4-dinitrophenyl conjugates in vivo. The immunogenicity and tolerogenicity of 2,4-dinitrophenyl (DNP) conjugates of levan, type 3 pneumococcal polysaccharide (SIII), dextran B512 and dextran B 1299 with different levels of substitution were assessed in vivo. It was confirmed that, as...

Smith J.W., 1974: Geochemistry of oil-shale genesis in the Piceance Creek Basin, Colorado. Field Conference - Rocky Mountain Association of Geologists 25, Guideb

Mahe, C.; Chevret, S., 1999: Estimation of the treatment effect in a clinical trial when recurrent events define the endpoint. Recurrent events are frequently encountered in clinical trials when individuals may experience an event more than once. Examples are common in medical research, including infectious episodes, myocardial infarctions and hospital admissions. However...

Izeradjene, K.; Hingorani, S.R., 2007: Targets, trials, and travails in pancreas cancer. Pancreas cancer is a highly aggressive and rapidly fatal disease. The current standard of care for advanced disease improves survival modestly at best and provides palliation for a minority of patients. The need for new therapies is undisputed. Th...