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Nephrotoxicity of cyclosporine A and amphotericin B-deoxycholate as continuous infusion in allogenic stem cell transplantation


, : Nephrotoxicity of cyclosporine A and amphotericin B-deoxycholate as continuous infusion in allogenic stem cell transplantation. Swiss Medical Weekly 132(23-24): 316-320

Background: Nephrotoxicity is an important side effect of amphothericin B deoxycholate (ampho B) and cyclosporine A (CsA). The combined administration of these drugs is frequent in patients with haematological diseases undergoing allogeneic stem cell transplantation. Aim: To assess the additional renal toxicity of ampho B given as a continuous infusion in addition to CsA. Methods: In a retrospective study renal function was investigated in patients receiving CsA alone or in combination with ampho B (24-hour infusion) after allogeneic stem cell transplantation between January 1998 and April 2001. Results: Of a total of 84 patients, 22 were treated with ampho B. There was a statistically significant decline in renal function in comparison to the 62 patients receiving CsA alone. However, renal insufficiency in all patients remained in a clinically acceptable range and was reversible. The residual renal dysfunction at the end of the hospitalisation was mainly due to continuing therapy with CsA. Conclusion: Amphotericin B deoxycholate in addition to CsA leads to a statistically significant but clinically tolerable worsening of renal function. Using a 24-hour infusion and strict salt repletion, amphotericin B can be administered safely as deoxycholate in bone marrow transplant patients in conjunction with CsA for proven or suspected fungal infections.

US$19.90

PMID: 12362282

DOI: 2002/23/smw-10004


Other references

Lange, W., 1969: Cytogenetic and embryological studies of crosses between H. vulgare and H. bulbosum. Of the possible crosses between diploid H. vulgare (W) and H. bulbosum (BB) and their autotetra-ploids, crosses between VV and BB yielded three haploid V plants and three diploid hybrids; VV x BBBB gave one haploid V plant and 145 triploid hybrids...

Pujante, I.M.; Moyano, F.J.; Martos-Sitcha, J.A.; Mancera, J.M.; Martínez-Rodríguez, G., 2017: Effect of different salinities on gene expression and activity of digestive enzymes in the thick-lipped grey mullet (Chelon labrosus). The effects of different environmental salinities (0, 12, 40, and 55 ppt) on pepsinogen 2 (pga2), trypsinogen 2 (try2), chymotrypsinogen (ctr), and pancreatic alpha-amylase (amy2a) gene expression, and on the total activities of their correspondi...

Benzadon, J., 1942: Proceedings of the Sociedad de Obstetricia y Ginecologia de Rosario. Miguel Balaguer, Syphilis in pregnancy; Pablo Borras, Surgical treatment of utero-vaginal prolapse; G. Ricci, N. Rodriguez Miranda and M. Balaguer, Treatment of obstetrical shock; J. C. Gosende, Pituitrin in forceps technic; and Alberto Baraldi an...

Akman, Y.; Ketenoglu, O., 1976: The phytosociological and phyto ecological investigation on the ayas mountains turkey. The study includes the forested and deforested vegetation of the Ayas Mountain, situated at a distance of 40 km west of Ankara. The forested vegetation on the Ayas mountains consists of Pinus nigra ssp. pallasiana and Quercus pubescens. Here Cistu...

Ross Ascuitto N.; Ascuitto R.; Ramage D.; Mcdonough K., 1989: Mechanical and metabolic function of the neonatal pig heart during low flow ischemia ischemic arrest and reperfusion. Pediatric Research 25(4 PART 2): 244A

Romero, P.; Dodd, I.C.; Martinez-Cutillas, A., 2012: Contrasting physiological effects of partial root zone drying in field-grown grapevine (Vitis vinifera L. cv. Monastrell) according to total soil water availability. Different spatial distributions of soil moisture were imposed on field-grown grapevines by applying the same irrigation volumes to the entire (DI; deficit irrigation) or part of the (PRD; partial root zone drying) root zone. Five treatments were a...

Iwasaki, Y.; Oiso, Y.; Saito, H.; Majzoub, J.A., 1997: Positive and negative regulation of the rat vasopressin gene promoter. To study the transcriptional regulation of the vasopressin gene in vitro, 3 kb of the 5' regulatory region of the rat vasopressin gene was isolated and subcloned, along with a series of various deletion mutants, into vectors containing the lu...

Barakat, H.A.; Brown, W.E.; Dohm, G.L., 1977: Oxidation of leucine by heart and muscle homogenates of the cardio myopathic hamster. The oxidation of leucine was measured in heart muscle homogenates of cardiomyopathic and normal hamsters at 3 ages. Leucine oxidation was significantly decreased in heart but increased in muscle. The activity of leucine .alpha.-ketoglutarate trans...

Ludden, P.A.; Carter, D.E.; Nayigihugu, V.; Scholljegerdes, E.J.; Townsend, R.S.; Hess, B.W.; Rule, D.C., 2002: Effect of ruminal protein degradability and supplementation frequency on lamb growth and gastrointestinal organ mass. Journal of Animal Science 80(Supplement 2): 137

Ewing, Keith Lowell, 1963: Hematological effects in C57BL/6 mice fed selected Tweens. Dissert Absts 24(1): 360-361