geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Nitrite plasma levels in acute and chronic coronary heart disease


, : Nitrite plasma levels in acute and chronic coronary heart disease. Minerva Cardioangiologica 45(11): 553-558

The authors carried out a study on the plasmatic levels of nitrites, which are the sole stable metabolites of nitric oxide (NO), in a group of subjects suffering from various clinical forms of coronary artery disease, aimed at evaluating the endothelial production of NO in acute and chronic ischemic conditions. Our series consisted of 104 female subjects (mean age 65 +/- 5) subdivided into: a) 10 subjects with acute coronary heart disease (myocardial infarction); b) 32 with chronic non hypertensive coronary heart disease (CHD); c) 30 with hypertensive CHD (arterial blood pressure over 160/95 mmHg); d) 32 with CHD and hypercholesterolemia (values over 250 mg/dl). Thirty-seven female subjects (mean age 58 +/- 7) without internistic diseases were considered as control subjects. For each sample the plasmatic levels of nitrites were determined by the Gutman and Hollywood method. We discovered that in the patients with chronic coronary heart disease (CHD) the mean value of nitrites was 18 +/- 0.3 mumol/L, not significantly different from the controls (17 +/- 0.5 mumol/L). In the patients with acute CHD the nitrite plasma level were significantly (p < 0.05) higher (30 +/- 2.2 mumol/L) compared to the controls and the patients with chronic CHD. In the group of patients with hypertensive CHD the mean nitrite value was 20 +/- 0.6 mumol/L, significantly (p < 0.05) higher in comparison with the group of non-hypertensive CHD patients (14 +/- 0.3 mumol/L). In the subjects with CHD and hypercholesterolemia the mean value of nitrites was sharply elevated, (25 +/- 1.0 mumol/L), with a highly significant difference (p < 0.01) as compared to the normolipemic CHD patients. These results lead to the hypothesis that: strong NO production may play a compensatory and protective role during acute myocardial hypoxia; NO defective synthesis may depend on an exhaustive endothelial adjustment in subjects with long-term CHD; a significant increase of the relaxing factor in hypertensive conditions exists; a highly enhanced synthesis of the plasmatic nitrites in hypercholesterolemic patients means an engagement of NO to neutralize the endothelium-damaging molecular substances and particularly the oxided LDL.

US$29.90

PMID: 9549288


Other references

Ergeneman, O.; Chatzipirpiridis, G.; Gelderblom, F.B.; Pokki, J.; Pané, S.; Marín Suárez Del Toro, M.; Fernández Sánchez, J.F.; Sotiriou, G.A.; Nelson, B.J., 2011: Oxygen sensing using microrobots. We present a luminescence oxygen sensor incorporated in a wireless intraocular microrobot for minimally-invasive diagnosis. This microrobot can be accurately controlled in the intraocular cavity by applying magnetic fields. The microrobot consists...

Szabo, C.; Masiello, A.; Ryan, J.F.; Brody, L.C., 2000: The breast cancer information core: database design, structure, and scope. The Breast Cancer Information Core (BIC) is an open access, on-line mutation database for breast cancer susceptibility genes. In addition to creating a catalogue of all mutations and polymorphisms in breast cancer susceptibility genes, a principle...

Matthews, K.R.; Jayarao, B.M.; Oliver, S.P., 1992: Plasmid pattern analysis of Staphylococcus species isolated from bovine mammary secretions. Plasmid profiles of staphylococci isolated from bovine mammary secretions were heterogeneous as shown by the study of 94 isolates representing six species. Plasmids were identified in 19 of 94 staphylococcal isolates. Number of plasmids per isolat...

Pour, L.; Mohammadi, M.; Khodakaramian, G.; Moghadam, B.Soheili., 2016: Phenotypic And Molecular Differentiation Of Pectobacterium And Dickeya Spp. Causing Potato Tuber And Stem Rot In North-Western Provinces Of Iran. Iran is one of the most important potato-producing countries in Asia and Oceania. Approximately 20 percent of potato cultivation in Iran occurs in the North-western provinces. Pectobacterium and Dickeya species cause important diseases in potato c...

Meletti, P., 1959: On the origin of a hexaploid Triticum, wild Denti de Cani in Sardinia. Views previously expressed concerning the origin of this wheat by hybridization between Triticum durum and Haynaldia villosa are supported by the occurrence of 60 plants of Denti de Cani, with 2n = 42, in the progeny of two typical ears of T. duru...

Gouda, J.; Prusty, R.Kumar., 2014: Overweight and obesity among women by economic stratum in urban India. Using data of the third round of the National Family Health Survey (NFHS) 2005-2006, this study examined the prevalence of overweight and obesity among women from different economic strata in urban India. The study used a separate wealth index for...

Mitrofanov M.P., 1979: Interrelationships between athero sclerotic changes of various arterial basins. The evaluation of atherosclerosis of 310 sets of arteries stained with Sudan IV was done visually by the planimetric method using the WHO criteria. Based on the evaluation in each case of 52 arterial segments, standardized values were calculated f...

Pegram, G.; Mohamed Parak, 2004: A review of the regional maximum flood and rational formula using geomorphological information and observed floods. Flood estimation methods in South Africa are based on three general approaches: empirical, deterministic and probabilistic. The "quick" methods often used as checks are the regional maximum flood (RMF) and the rational formula (RF), whic...

Wightman, J.A.; Morrison, G., 1978: Wireworms (Coleoptera: Elateridae) associated with damaged onions and garlic crops near Blenheim. Damage caused by elaterid larvae was thought to have contributed to badly stunted plants and reduced yields of onion and garlic in the Blenheim area of New Zealand in 1972. Observations in 1973 indicated that Ctenicera strangulata (White) was pres...

Spychalski, E.; Blaszczyk, Z., 1976: Case of primary appendiceal carcinoma. Wiadomosci Lekarskie 29(19): 1757-1760