+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Pentoxifylline improves resting membrane potential in sepsis

, : Pentoxifylline improves resting membrane potential in sepsis. Journal of Pediatric Surgery 28(9): 1144-1146

The resting membrane potential (RMP) of skeletal muscle cells was investigated in a hyperdynamic animal model of sepsis. Reduced membrane potential is known to parallel the clinical course of sepsis and hemorrhagic shock in animal models. Pentoxifylline (PTF), a dimethyl xanthine derivative of the theophylline family, may improve the metabolic effects of sepsis. A cecal ligation and puncture (CL&P) sepsis model in Wistar rats was used in which RMP was measured with differing administration regimes of PTF. The RMP decreased less rapidly in our study when PTF was administered after CL&P and this effect was most noticeable after 18 hours. Administration of PTF before CL&P had little effect on membrane potential fall-off. These results suggest a potential role for PTF in the management of sepsis.


PMID: 8308680

Other references

Nitescu, E.; Mihnea, I.; Cojocaru, I.; Grosu, M.; Leu, D.; Toma, S.; Nicolau, A., 1988: Solutions and experimental results with a view to improving drainage in clay soils. Investigations conducted in north-east Romania, where over 80% of the areas consists of slowly permeable and saline soils, have shown that certain clayey soils lose within one year the improved permeability achieved by deep loosening. Calcium amen...

Gratrix, J.; Bergman, J.; Egan, C.; Drews, S.J.; Read, R.; Singh, A.E., 2014: Retrospective review of pharyngeal gonorrhea treatment failures in Alberta, Canada. Our review of Neisseria gonorrhoeae pharyngeal treatment failures from sexually transmitted infection clinics in Alberta suggests that treatment failures with oral cefixime monotherapy were not related to elevated cefixime minimum inhibitory conce...

Feld, G., 1972: School at the sickbed. Krankenpflege 26(2): 76-76

Anonymous, 2007: 4 calculations for atoms used for the data generation. Journal of the Icru 7(1): 57-76

Schachter, M., 2014: Affective and psychomotor regression in uniovular twins. Archives Internationales de Neurologie, des Maladies Hereditaires, de Medecine Mentale et Psychosomatique 69(10): 170-173

Reyners H.; Reyners E.G.D.; Jadin J M.; Maisin J., 1975: The subsurface cisterns of the endoplasmic reticulum and their relationships with the astrocyte feet in contact with the neurons in the cerebral cortex. Journal de Microscopie et de Biologie Cellulaire 23(2): 71A

Davidson, L.; Tondora, J.; O'Connell, M.J.; Kirk, T.; Rockholz, P.; Evans, A.C., 2007: Creating a recovery-oriented system of behavioral health care: moving from concept to reality. This article describes challenges and successes seen in the first four years of efforts the state of Connecticut has made to reorient its behavioral health system to promoting recovery. Beginning in 2000, the Connecticut initiative was conceptuali...

Gallagher, J.M.; Brown, M.E.; Gasior, T.A., 1995: Combined use of aprotinin and a heparin-bonded cardiopulmonary bypass system for aortic aneurysm repair. Journal of Cardiothoracic and Vascular Anesthesia 9(6): 728-730

Alchas, P.G.; Prais, A.W.; Jarrell, B.E.; Williams, S.K.; Dipisa, J.A.Jr, 1994: Device and method for collecting and processing fat tissue and procuring microvessel endothelial cells to produce endothelial cell product. Official Gazette of the United States Patent & Trademark Office Patents 1169(2): 1107, Dec 13

Mertelsmann, R.; Lindemann, A.; Oster, W.; Gamm, H.; Kolbe, K.; Herrmann, F., 1990: Hematopoietic growth factors in oncology. Hematopoietic growth factors, or hemopoietins, are peptide hormones produced by peripheral blood cells, bone marrow stroma, as well as several other cell types, such as endothelial cells and fibroblasts. Hemopoietins play a central role in regulat...