+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Peroperative parathyroid hormone assay: assurance of successful surgical treatment of primary hyperparathyroidism

, : Peroperative parathyroid hormone assay: assurance of successful surgical treatment of primary hyperparathyroidism. Nederlands Tijdschrift Voor Geneeskunde 143(14): 742-746

To study the reliability and applicability of a rapid parathormone (PTH) test as predictor of successful surgical treatment of primary hyperparathyroidism. Prospective. All 35 consecutive patients undergoing surgery for primary hyperparathyroidism in the University Hospital Utrecht, the Netherlands, in august 1997-august 1998, were tested just prior to surgery, and immediately following adenomectomy. The rapid PTH test consisted of a modification of the computerized immunometric detection by chemoluminescence. The decrease of serum PTH as estimated with the rapid test was correlated with surgical findings as well as postoperative serum calcium levels. In the first 25 patients (group A) the reliability of the test was investigated. In the next 10 patients (group B) the PTH test results were allowed to have implications for surgical management, i.e. an insufficient (< 50%) decrease of serum PTH following adenomectomy resulted in immediate re-exploration. The 35 patients, 22 women and 13 men, had a median age of 58 years (range: 22-80). The results obtained with our rapid PTH test correlated fully with both conventional PTH measurement techniques and postoperative serum calcium levels. In group A 21/25 patients showed adequate (> 50%) decrease of their serum PTH levels; the 4 patients without such decrease were the ones displaying persistent postoperative hypercalcaemia. In group B 9/10 patients had adequate PTH decrease immediately following adenomectomy, while in one patient this was only attained after further exploration and excision of a second adenoma. No false-positive or false-negative measurements were encountered. The rapid PTH test used is a reliable predictor of successful adenomectomy for primary hyperparathyroidism, also in minimally invasive surgery.


PMID: 10347629

Other references

Kuzniar, T.J.; Morgenthaler, T.I.; Afessa, B.; Lim, K.G., 2007: Chronic cough from the patient's perspective. OBJECTIVE: To identify the factors that patients consider most concerning about their cough.PATIENTS AND METHODS: All consecutive patients Who presented with a complaint of chronic cough between November 1, 2000, and February 28, 2001, were prosp...

Absher, R.K.; Moore, M.Elisabeth.; Parker, M.H., 2002: Patient-specific factors predictive of warfarin dosage requirements. OBJECTIVE: To identify patient-specific factors predictive of maintenance warfarin dosage requirements >5 mg/d. METHODS: One hundred forty-six adults taking warfarin were identified from a community hospital and an outpatient anticoagulation cl...

Wadas, T.J.; Deng, H.; Sprague, J.E.; Zheleznyak, A.; Weilbaecher, K.N.; Anderson, C.J., 2009: Targeting the alphavbeta3 integrin for small-animal PET/CT of osteolytic bone metastases. This article describes the evaluation of the radiopharmaceutical (64)Cu-CB-TE2A-c(RGDyK) ((64)Cu-RGD) as an imaging agent for osteolytic bone metastases and their associated inflammation by targeting of the alpha(v)beta(3) integrin on osteoclasts...

Vieira, R.D.; Pereira, A.C.; Lima, E.G.; Garzillo, C.L.; Rezende, P.Cury.; Favarato, D.; Hueb, A.C.; Gersh, B.J.; Ramires, Jé.A.F.; Hueb, W., 2012: Cancer-related deaths among different treatment options in chronic coronary artery disease: results of a 6-year follow-up of the MASS II study. The primary end points of randomized clinical trials evaluating the outcome of therapeutic strategies for coronary artery disease (CAD) have included nonfatal acute myocardial infarction, the need for further revascularization, and overall mortali...

Stabel, J.R.; Goff, J.P., 1990: Effect of periparturient stress on plasma retinol, alpha -tocopherol and zinc concentrations in dairy cows. 18 Jersey cows were used to determine the effects of parturition, lactation and peri-parturient calcium status on plasma retinol, alpha -tocopherol and zinc concn. during the 2 wk before and after parturition. Plasma levels by day 1 post partum ha...

Boyce, S.G., 1951: Source of atmospheric salts. Science 113(2944): 620-621

Soto E.; Perez M.E.; Vega R., 1988: Naloxone induces an excitatory effect on the vestibular system primary afferents. Society for Neuroscience Abstracts 14(1): 331

Ostrowska, Z.; Zwirska Korczala, K.; Buntner, B., 1995: The circadian rhythm of serum thyrotropin level in sham-operated and pinealectomized rats effect of prolonged melatonin administration. The effect of pinealectomy and prolonged melatonin administration (100 mu-g/100 g body weight, interaperitoneally - twice daily over a one month period) on thyrotropin (TSH) secretion in sexually mature rats was examined (RIA method) at 3-h interv...

Guerriere, M., 2000: Forces for change in Canadian healthcare. Hospital Quarterly 3(1): 14-20

Due-Tonnessen, P.; Rasmussen, I.; Berntsen, E.Magnus.; Bjornerud, A.; Emblem, K.E., 2014: Identifying the central sulcus in patients with intra-axial lesions: a multicenter study comparing conventional presurgical MRI to topographical analysis and BOLD-fMRI. Identification of eloquent brain areas in patients with intra-axial lesions is important to minimize the risk of neurological deficit. We performed a multicenter study comparing conventional 2-dimensional magnetic resonance imaging (MRI) for ident...