+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Pituitary pseudotumor with unusual presentation reversed shortly after the introduction of thyroxine replacement therapy

, : Pituitary pseudotumor with unusual presentation reversed shortly after the introduction of thyroxine replacement therapy. Journal of Pediatric Endocrinology & Metabolism 14(9): 1665-1669

Pituitary pseudotumor (pituitary thyrotroph hyperplasia) caused by unrecognized and untreated hypothyroidism has been described as a rare condition, mostly in adults. There are only a few reports on this condition in children. Here we describe an unusual association of pituitary pseudotumor with hypothyroidism, vaginal bleeding, and growth retardation in a girl at an early stage of puberty. Hormonal testing showed low thyroxine and high TSH levels, hyperprolactinemia, low growth hormone levels and prepubertal levels of gonadotrophins. Ovarian cyst was detected by ultrasound. A large intrasellar mass expanding beyond the sella turcica was detected on MRI. Homogeneous contrast enhancement confirmed pituitary hyperplasia. Therapy with L-thyroxine resulted in rapid improvement of the clinical signs, normalization of the hormone levels, and resolution of the pituitary hyperplasia on MRI within 40 days. In children, prolonged unrecognized primary hypothyroidism might be accompanied by growth deficiency and pubertal disharmony. Pituitary hyperplasia should be sought in these cases.


PMID: 11795659

Other references

Bladé, J.; Rosiñol, L.; Cibeira, M.Teresa.; Rovira, M.; Carreras, E., 2010: Hematopoietic stem cell transplantation for multiple myeloma beyond 2010. Autologous stem cell transplantation (ASCT) is considered the gold standard in the frontline therapy of younger patients with multiple myeloma because it results in higher complete remission (CR) rates and longer event-free survival than conventio...

Nasseri, K.; Ko, Y.H., 1977: Epidemiology of leprosy in Iran. A total of 907 cases of leprosy from two sources, records from Baba-Baghi Leprosarium (709 cases) and Ahar case finding survey (198 cases), have been studied. The main characteristics of the cases are: a) about 50% of all cases are lepromatous lep...

Aggarwal, S.Kumar.; Nath, A.; Singh, R.; Keshri, A., 2013: Lemierre's Syndrome presenting with neurological and pulmonary symptoms: Case report and review of the literature. Lemierre's Syndrome (LS) is a potentially life-threatening condition, characterized by clinical or radiologic evidence of internal jugular vein thrombosis following an oropharyngeal infection, most commonly by Fusobacterium necrophorum. A hig...

LeVarlet Xavier Y.A.; Hage Joniek I.; van Daele Patrick, 1998: Runib Field; a fit-for-purpose, integrated 3-D static and dynamic modeling study. GeoArabia (Manama) 3(1): 115-116

Tumikyan G.G., 1963: The south structure-a promising new prospect in the apsheron oil district. Neftegazovaya Geologiya i Geofizika 7: 36-38

Ryan, M.T.; Sweeney, T., 2006: Genetic susceptibility to scrapie in sheep: a clinically relevant theme in veterinary medical education. This article describes and evaluates two molecular biology practical classes based around the theme of genetic susceptibility to scrapie in sheep. These practical classes allow students to experience a range of molecular biology techniques in the...

Stavkova, J.; Turcinkova, J., 2005: Consumer choice process when purchasing the staple food. After 1989, there were significant changes in food consumption in the Czech Republic, both in volume and structure. These changes happened due to various factors, including: the development of income levels; the development of the consumer prices...

Hughes, A.S.; Murphy, R.J.; Gibson, J.F.; Cornfield, J.A., 1994: Electron paramagnetic resonance (EPR) spectroscopic analysis of copper based preservatives in Pinus sylvestris. Electron paramagnetic resonance (EPR) spectroscopy was used to investigate the forms of copper present in Pinus sylvestris wood treated with several wood preservative formulations. Anisotropic Cu(II) signals, indicative of immobile Cu2+ ions were...

Rangelov B.K., 1983: Estimation of the optimal equipment magnification of the Bulgarian national telemetric system for seismic information (NTSSI). 15: 23-26 1983

Meijer, J.F.M.; Bultsma, T.; Zaagsma, J.; Zuiderveld, O.P.; Nauta, W.T., 1977: Biologically active compounds via di aryl methylene derivatives as intermediates part 2 biological activities of n aminoalkyldiaryl ketimines. Several substituted N-aminoalkyldiarylketimines were studied for biological activity in some pharmacological testing systems (antihistamine) [guinea pig ileum], antiacetylcholine [rat jejunum], antinoradrenaline [antinorepinephrine], [rat vas defe...