geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Postnatal glucocorticosteroid therapy for treatment and prevention of neonatal chronic lung disease


, : Postnatal glucocorticosteroid therapy for treatment and prevention of neonatal chronic lung disease. Expert Opinion on Investigational Drugs 9(1): 53-67

Neonatal chronic lung disease (CLD) is a persistent complication, primarily of premature infants. Postnatal glucocorticoid therapy is widely used in the treatment and prevention of CLD. Most studies reveal acute improvement in the pulmonary status of infants treated with postnatal glucocorticoid therapy. Recent studies of 'earlier' intervention (< 14 days of age) demonstrated a reduction in mortality and in the occurrence of CLD between 28 days of age and 36 weeks postmenstrual age. Great concern remains, however, regarding the potential adverse outcomes, including growth inhibition, infection, catastrophic GI complications and CNS injury. Therefore, the use of postnatal glucocorticoid therapy remains controversial with respect to the clinical indications for initiating therapy, the dose, duration, onset and route of administration, as well as potential benefits and risks. Inhaled glucocorticoid therapy is increasingly used to treat and prevent CLD in order to avoid adverse effects of high dose systemic glucocorticoid therapy. Recent studies with inhaled glucocorticoid therapy show promise. Further work, however, for improving aerosol delivery and deposition, will be needed to refine their role in the prevention and treatment of CLD. Future studies enabling early, accurate identification of infants at greatest risk for CLD, coupled with a more comprehensive understanding of the different pathogeneses, will provide information regarding appropriate timing of onset, dosing, route of therapy and duration of intervention.

US$19.90

PMID: 11060660

DOI: 10.1517/13543784.9.1.53


Other references

Zimpfer, M.; Schuetz, W.; Raberger, G., 1977: Hemodynamic and coronary actions of ouabain during coronary infusion. Investigations were carried out on 24 mongrel dogs anesthetized with chloralose or sodium pentobarbital. Ouabain was added to coronary blood (50, 100 and 200 ng/ml coronary blood or 0.7, 1.4 and 2.8 .times. 10-7 M) over periods of 30 or 60 min by...

Liu, H.M.; Gao, F.Y.; Yu, H.; Meng, P.P.; Jiang, Y.Y.; Wang, X.B., 2016: Screening of serum biomarkers by isobaric tags for relative and absolute quantitation in patients with HBV-related acute-on-chronic liver failure. NlmCategory="UNASSIGNED"><b>Objective:</b> To investigate the screening of serum biomarkers in patients with HBV-related acute-on-chronic liver failure (HBV-ACLF) by isobaric tags for relative and absolute quantitation (iT...

Meunier, L.; Beauvais, L.; Costes, Y.; Barnéon, G.; Pages, A.; Meynadier, J., 1988: Epidermotropic and junctional metastases of malignant melanoma. Annales de Dermatologie et de Venereologie 115(12): 1279-1280

McComb, J.A.; Goldstein, D.B., 1979: Quantitative comparison of physical dependence on tertiary butanol and ethanol in mice: correlation with lipid solubility. Mice were made physically dependent on t-butanol and the withdrawal reaction was compared quantitatively with that produced by ethanol. The mice inhaled t-butanol vapor (50-140 mumol/1 of air) continuously for 1, 3, 6 or 9 days. Daily t-butanol bl...

Kuate Defo, B., 1988: Causes of infant-child mortality in Yaounde. This study identifies the causes of infant and child mortality (EMIJ) in Yaounde, Cameroon based on findings from The Institute de Formation et de Recherche Demographique (IFORD) survey that took place from January 1, 1978 to January 31, 1980. The...

Giudici, P.; Pallini, G.; Varola, A., 1994: Ammoniti e fossili associati del Campaniano sommitale zona a N hyatti nel Salento Lecce-Italia meridionale. A unique, new ammonite fauna of some hundred adult specimens is referred to Nostoceras gr. hyatti Stephenson (80% of the ammonite association) and, limitedly (20% of the ammonite association), to Solenoceras gr. multicostatum Stephenson. The fossi...

Luisada, A.A.; Argano, B., 1970: The phonocardiogram in systemic hypertension. Chest 58(6): 598-600

Chester, J.D.; Joel, S.P.; Cheeseman, S.L.; Hall, G.D.; Braun, M.S.; Perry, J.; Davis, T.; Button, C.J.; Seymour, M.T., 2003: Phase I and pharmacokinetic study of intravenous irinotecan plus oral ciclosporin in patients with fuorouracil-refractory metastatic colon cancer. To assess the safety and toxicity profile of escalating doses of intravenous irinotecan, in combination with a fixed dose of oral ciclosporin (Cs) and to determine the pharmacokinetic profile of irinotecan and its metabolites. Patients with fluoro...

Lorca, T.; Cavadore, J.C.aude; Devault, A.; Fesquet, D.; Labbe, J.C.aude; Doree, M., 1993: Mechanisms involved in activation and inactivation of cyclin-dependent protein kinases. Guigon, M [Editor], Lemoine, F M [Editor], Dianiak, N [Editor], Schechter, A [Editor], Najman, A [Editor] [INSERM Colloquium; The negative regulation of hematopoiesis: From fundamental aspects to clinical applications] Colloque INSERM; The negative regulation of hematopoiesis: From fundamental aspects to clinical applications 65-73

Haim, G.; Albers, L., 1973: Periodontal diseases and gastritis. Deutsche Zahnarztliche Zeitschrift 28(4): 481-485