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Preliminary studies for interaction of a cyclobutane thymine dimer region with its cognate antibody

, : Preliminary studies for interaction of a cyclobutane thymine dimer region with its cognate antibody. Nucleic Acids Symposium Series: 281-282

A monoclonal antibody (TDM-2) specific to a UV-induced cyclobutane pyrimidine dimer has previously been established. We investigated here the structural requirements of antigen recognition by the antibody using chemically synthesized antigen analogs. TDM-2 bound to the cis-syn, but not the trans-syn thymine dimer, and recognized not only the cyclobutane ring but also the 5'- or 3'-side phosphate groups flanking the cyclobutane dimer site. The antibody showed strong binding to photodimer-containing single stranded DNA but indicated little binding to double stranded DNA.


PMID: 9586109

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