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Propofol versus diazepam. Sedation in ophthalmologic surgery under local anesthesia


, : Propofol versus diazepam. Sedation in ophthalmologic surgery under local anesthesia. Der Anaesthesist 42(11): 766-772

This prospective study was designed to evaluate the sedative effect of two different anaesthetic drugs in patients undergoing ophthalmic surgery. Propofol is an intravenous hypnotic agent with a short half-life of about 30 min. A constant high oxygen saturation in continuous pulse oximetry was achieved in previous studies using propofol for sedation. Furthermore, an IOP-lowering effect was proved. Propofol was compared to diazepam, a well-established sedative, which has been used for many years for sedation of patients in local anaesthesia. METHOD. One hundred patients of comparable anaesthesiologic risk (ASA classes 2-4) undergoing identical surgical procedures received either propofol (n = 50), or diazepam (n = 50). Propofol was infused at a rate of 0.8-3.0 mg/kg/h, while diazepam was given as a slow intravenous bolus of 5 mg before surgery. All patients were monitored by continuous pulse oximetry. RESULTS. Oxygen saturation of patients receiving propofol was never less than 96%. In contrast, oxygen saturation of patients sedated by diazepam dropped to 85%, especially for the first 5 min following administration, before improving to 95% during the next 10 min. None of the patients who received propofol showed signs of motor unrest, a great handicap in ophthalmic surgery, while four patients who received diazepam were restless enough to hamper the procedure. None of the patients who received propofol developed respiratory depression. In contrast, marked respiratory depression, motor agitation, and postoperative fatigue slowing mobilization were common in patients who received diazepam.

US$29.90

PMID: 8279689


Other references

Ullinger, J., 2002: A dental reconstruction of biological relationships in the Late Bronze and Early Iron Ages of the southern Levant. American Journal of Physical Anthropology Supplement (34): 158

Whitehead, S.; Lemenson, G.; Browse, N.L., 1983: The assessment of calf pump function by isotope plethysmography. A method of measuring the function of the calf muscle pump using in vivo 99Tcm-labelled red cells is described. This new, non-invasive method can provide detailed information about the emptying and refilling of the deep and superficial veins of th...

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Dombek K.M.; Carey V.C.; Ingram L.O., 1982: The localization of the effect of ethanol in biological membranes. Abstracts of the Annual Meeting of the American Society for Microbiology 82: ABSTRACT K164

Turner, N.; Armitage, M.; Butler, R.; Ireland, G., 2004: An in vitro model to evaluate cell adhesion to metals used in implantation shows significant differences between palladium and gold or platinum. Adhesion of tissue cells to metallic implants is a major factor that is important for proper tissue integration. Adhesion of Swiss mouse 3T3 fibroblasts to gold, platinum and palladium surfaces was investigated. Immunofluorescence staining for the...

Brown, R.D.; Matthews, K.S., 1979: Chemical modification of lactose repressor protein using N-substituted maleimides. Lactose repressor protein has been modified with N-ethylmaleimide, two N-maleimide spin labels, and an N-maleimide fluorophore. The reaction with repressor cysteine residues has been characterized. Approximately 2 of the 3 eq of cysteine/repressor...

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Zuk, M.S.mmons, L., 1997: Reproductive strategies of the crickets (Orthoptera: Gryllidae). Evolution of mating systems in insects and arachnids 09

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