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Prostate-specific membrane antigen is produced in tumor-associated neovasculature

, : Prostate-specific membrane antigen is produced in tumor-associated neovasculature. Clinical Cancer Research 5(10): 2674-2681

Prostate-specific membrane antigen (PSMA), a type II transmembrane protein, was originally thought to be strictly expressed in prostatic tissue, but recent studies have demonstrated PSMA protein expression in nonprostatic tumor neovasculature as well. Using immunohistochemistry, reverse transcription-PCR assays, and in situ hybridization, we have demonstrated PSMA mRNA transcripts and protein expression in the endothelium of tumor-associated neovasculature of multiple nonprostatic solid malignancies. In addition, we found no PSMA mRNA or protein expression in the vascular endothelial cells of corresponding benign tissue examples. Our findings expand the possible therapeutic role of PSMA and establish it as a unique biomarker specifically produced and expressed by tumor-associated neovasculature but not produced or expressed by normal vessels.


PMID: 10537328

Other references

Ozeti, N.; Atatur, M., 1981: A preliminary survey of the serum-proteins of a population of Mertensiella luschani finikensis Basoglu and Atatur from Finike in southwestern Anatolia. Istanbul Universitesi Fen Fakultesi Mecmuasi Seri B. 1979 ; 44: 23-29

Riso Ricardo D.; L.C.rre Pierre; L.H.lguen Stephane; Morin Pascal, 2004: On the presence of a cadmium-rich subsurface water mass in the western Mediterranean and its influence on the distribution of cadmium in the surface waters. Vertical distribution of cadmium (27-133 pM) at 13 stations in the Alboran Sea (western Mediterranean) showed profiles that were different from those typically known from oceanic waters. A subsurface cadmium-rich layer, related to the presence of...

Hamilton, D.Kirk., 2011: What constitutes best practice in healthcare design?. Herd 4(2): 121-126

Soc Catalana Oto Rino Laringol, 1972: Meeting of the sociedad catalana de oto rino laringologia catalonian society of oto rhino laryngology june 16 1971. Anales de Medicina Especialidades 58(1): 42-54

Linton, D.; Sudduth, A., 2011: Food allergies in the hospital setting: prevention, treatment and patient education. Nursing for Women's Health 15(4): 330-333

Felizola, S.J.A.; Nakamura, Y.; Hui, X-Gang.; Satoh, F.; Morimoto, R.; M McNamara, K.; Midorikawa, S.; Suzuki, S.; Rainey, W.E.; Sasano, H., 2013: Estrogen-related receptor α in normal adrenal cortex and adrenocortical tumors: involvement in development and oncogenesis. The nuclear hormone receptor estrogen-related receptor α (ERRα) regulates the activation of mitochondrial genes in various human tissues, but its role in the adrenal gland and its disorders has not been defined. Therefore, we examined ERRα expr...

Chen, Y-W.; Chen, M-H.; Wang, L-M.; Chen, Y-C., 2007: Spontaneous intramural intestinal haematoma. Internal Medicine Journal 37(9): 661-662

Grigorovich, N.A.; Ivanov, M.T., 1967: Study of desoxy-ribonucleoprotein structure of the spleen and lungs in mice during the early period after irradiation and administration of urethane. The structure of desoxyribonucleoproteid [DNP] from the spleen and lungs of mice early after fractional gamma-irradiation and administration of urethane was studied. Immediately after irradiation and 24 hr. later destruction of the tertiary and qu...

Girin, S.V., 1999: Free radical processes at the combined chronic inhalation effect of xenobiotics to the rats organism. The chronic combined inhalation influence of nitric oxides (II, IV), amorphic hydrophobic silicon dioxide, lead and radon on the free radical processes intensively was investigated. The dienic conjugates, lipid hydroperoxides and MDA concentration...

Amati, A.; Marangoni, B.; Zironi, R.; Castellari, M.; Arfelli, G., 1994: Differentiated grape harvesting. The effects of cluster thinning on vine physiology. (IIIrd note). In trials on vines of grape cv. Trebbiano romagnolo, cluster thinning advanced and prolonged maximum sugar accumulation without promoting a faster decline in titratable acidity. The severity of cluster thinning seemed to be more important than the...