geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Quantitative cerebral blood flow imaging in a patient with the Heidenhain variant of Creutzfeldt-Jakob disease


, : Quantitative cerebral blood flow imaging in a patient with the Heidenhain variant of Creutzfeldt-Jakob disease. Clinical Nuclear Medicine 26(9): 770-773

This report describes quantitative SPECT cerebral blood flow (CBF) changes in a patient with the confirmed Heidenhain variant of Creutzfeldt-Jakob disease. A 60-year-old man reported visual disturbances, including left hemianopsia. An electroencephalogram, magnetic resonance imaging, cerebral arteriogram, and quantitative SPECT CBF imaging with Xe-133, with and without acetazolamide, were performed. After the patient's death, an autopsy was performed. The electroencephalographic findings were nonspecific, those of magnetic resonance imaging were normal, and the cerebral arteriogram showed minimal atherosclerosis. However, the SPECT scan revealed marked depression of perfusion in the parietal and occipital cortices that did not change with the administration of acetazolamide. Autopsy results were consistent with CJD. Although there is no consistent pattern of CBF changes that is characteristic of Creutzfeldt-Jakob disease, the Heidenhain variant of that disease may be an exception. Clinical symptoms include profound changes in vision, and the pattern of CBF changes in the patient described here included depression of perfusion in areas of primary and associated visual cortex. Also of interest is the finding that although other imaging did not reveal an abnormality, the CBF changes were marked. In addition, vasoreactivity is poor in response to acetazolamide, a finding that occurs only late in other neuronal degenerative conditions such as Alzheimer's disease.

US$29.90

PMID: 11507295


Other references

Mcpheeters, H.L., 1956: State hospital and discharge procedures. Journal of the Kentucky State Medical Association 54(6): 530; Passim-530; Passim

Tobin, G.; Rosén, A.; Rosenquist, R., 2005: What is the current evidence for antigen involvement in the development of chronic lymphocytic leukemia?. For many years it has been evident that B-cell chronic lymphocytic leukemia (CLL) displays preferential usage of individual immunoglobulin (Ig) variable heavy chain (V-H) genes. The V(H)1-69 gene was the first to be reported overrepresented in a l...

Blau, G., 1950: Heavy or light cows ?. The live weight of cows was related to their maintenance requirements, production level and economy of production, the latter being expressed in kg. starch equivalent per 1 kg. milk produced. Lactation and lifetime records were analysed. In the li...

Kiyohashi, A., 1981: Immunopotentiating action of streptococcal preparation OK-432 and protein-bound polysaccharide PS-K on depressed state of cell-mediated and humoral immunities of Friend leukemia virus infected mice. Nihon Gan Chiryo Gakkai Shi 16(4): 641-646

Bialkowski, S.; Kolataj, A., 1967: Effect of adrenaline on blood levels of glutathione in rabbits. Acta Physiologica Polonica 18(2): 241-246

Anonymous, 1986: The dilemmas of mothers who are physicians and of physicians who are mothers. JAMA 255(4): 464-467

Dawson, R.M.C., 1964: Physicochemical aspects of phos-pholipase action. The results discussed in this paper have indicated that when a phospholipase is in the presence of its lipid substrate the electrostatic conditions at the lipid-water interface may often be of paramount importance in determining the rate at which...

Stutts, E.C.; Johnson, W.; Briles, W.E.; Kunkel, H.O., 1956: Variation in reduced glutathione in bloods of inbred lines of chickens. Significant correlations were obtained between successive reduced glutathione (GSH) determinations, both in the same males and same females, thus indicating a high degree of constancy in level in individual chickens. The blood level of GSH was det...

McCarthy, M.P., 2015: Words of caution regarding research design when using the nutrition care process model. Journal of Renal Nutrition 25(1): 75-76

Siegel, Pb, 1979: Behaviour genetics in chickens; a review. World's poultry science journal 35(1): 9-19