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Radioimmunological image in tumor bearing nude mice with monoclonal antibody against human laryngeal carcinoma


, : Radioimmunological image in tumor bearing nude mice with monoclonal antibody against human laryngeal carcinoma. Zhonghua Er Bi Yan Hou Ke Za Zhi 33(1): 35-37

To investigate the specific autoradiographic diagnosis of laryngeal carcinoma and its metastasis. Three strains of the mixed monoclonal antibodies against human laryngeal carcinoma (McAbLC9, 11, 12) labelled with 131I were injected(intraperitoneally) into the nude mice bearing squamous cell carcinoma. The tumor autoradiography was done by single photo-emission computed tomography (ECT). The percent injected dose/g of tumor were measured, and the radioactivity ratio of tumor to non-tumor tissues(T/NT) were calculated. The 131I-McAbLC 9, 11, 12 can accumulate in the area of the laryngeal carcinoma within limited time, and demonstrate a satisfactory tumor imaging at 96 h. In experimental groups: The %ID/g of tumor tissues (mean +/- s, n = 6) was 18.8 +/- 0.61; The %ID/g of tumor tissues in the control group was 4.46 +/- 0.82 (mean +/- s, n = 6) at 96 h. The difference was statistically significant (P < 0.01, t = 34.97). The results suggest that 131I McAbLC9, 11, 12 is specific and sensitive in recognising human laryngeal carcinoma cell, and the area and size of tumor can be easily detected by ECT. It is feasible for localization of tumor and its metastasis.

US$29.90

PMID: 11498887


Other references

Houston, B.K., 1973: Viability of coping strategies, denial, and response to stress. Journal of Personality 41(1): 50-58

Grossman, Z., 1982: Recognition of self, balance of growth and competition: horizontal networks regulate immune responsiveness. The generation of immunologic specificity and the regulation of cellular growth are discussed. The classical clonal selection theory and later schemes involving lymphocyte networks or circuits postulate sets of specific recognition events which di...

Hudson, J.F.; Mullen, L.J., 1977: Costs and returns from fee fishing lakes in rural areas of Louisiana. Louisiana farmers and other rural landowners have expressed an interest in the feasibility of establishing rural recreational facilities. The Department of Agricultural Economics of the Louisiana Agricultural Experiment Station has therefore recen...

Gupta, S.R.; Rao, C.K.; Biswas, H.; Krishnaswami, A.K.; Wattal, B.L.; Raghavan, N.G., 1972: Role of the house-fly in the transmission of intestinal parasitic cysts-ova. In Delhi, India, groups of 300 Musca domestica were allowed to settle on faeces containing parasite larval stages and later examined to elucidate their role in transmission. 2 of 3 groups exposed to Ascaris lumbricoides and one of 2 exposed to Hym...

Bussadori, G., 1964: Some Considerations On The Phenomenon Of The Increase Of Average Height In Humans. L' Arcispedale S. Anna di Ferrara 17: 363-371

Zhao, J.; Jiang, C.; Lam, T.Hing.; Liu, B.; Cheng, K.Keung.; Xu, L.; A.Y.ung, S.Lun.; Zhang, W.; Leung, G.M.; Schooling, C.Mary., 2015: Genetically predicted testosterone and cardiovascular risk factors in men: a Mendelian randomization analysis in the Guangzhou Biobank Cohort Study. Observationally lower testosterone is associated with an unhealthier cardiovascular (CVD) risk profile, but this association is open to confounding and reverse causality. The authors examined the association of testosterone with well-established c...

Gallagher, I.M.; Clow, A.; Glover, V., 1998: Long-term administration of (-)-deprenyl increases mortality in male Wistar rats. Long-term administration of the monoamine oxidase inhibitor (-)-deprenyl (0.5 mg/Kg) for up to 20 months significantly increased mortality in the male Wistar rat, whereas the dopamine agonist pergolide (0.4 mg/Kg) and the antioxidant diethyldithio...

Dellamonica, J.; Lerolle, N.; Sargentini, C.; Hubert, S.; Beduneau, G.; D.M.rco, F.; Mercat, A.; Diehl, J.L.; Richard, J.C.M.; Bernardin, G.; Brochard, L., 2014: Effect of different seated positions on lung volume and oxygenation in acute respiratory distress syndrome. Lung volume available for ventilation is markedly decreased during acute respiratory distress syndrome. Body positioning may contribute to increase lung volume and partial verticalization is simple to perform. This study evaluated whether vertical...

Hearn, V.M.; Smith, Z.G.; Watkins, W.M., 1968: An a-N-acetyl-D-galactosaminyltransferase associated with the human blood-group A character. Biochemical Journal 109(2): 315-317

Annibaldi, S., 1957: Extraneous matter in Parmesan cheese.. The author used an American apparatus for the detection of foreign matter in cheese. He describes the sources of contamination in cheese and suggests methods for prevention.