+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Reduction of nausea and vomiting from epidural opioids by adding droperidol to the infusate in home-bound patients

, : Reduction of nausea and vomiting from epidural opioids by adding droperidol to the infusate in home-bound patients. Journal of Pain and Symptom Management 10(7): 544-547

In 184 adult patients with severe nonmalignant low back pain from postlaminectomy syndrome, temporary lumbar epidural catheters were infused with either 0.25% bupivacaine 92 mL, fentanyl 600 micrograms, and droperidol 5 mg (Group A), or 0.25% bupivacaine 92 mL, fentanyl 600 micrograms, and NaCl 0.9% 2 mL (Group B). Infusion rates ranged from 0.5 to 2 mL per hour, with an option for turning the infusion off when the patient had no pain and turning it on when the pain returned. Infusions were continued from 2 to 55 days, during which time the patient was at home. In Group A, only two patients had nausea without emesis, while in Group B, nausea occurred in 18 patients (P < 0.04) and four vomited (P < 0.05). The number of patients with headache, pruritus, somnolence, and/or numbness was minimal and without statistically significant group differences. During treatments, pain levels were 2 or less on a 10-cm visual analogue scale. Added to the epidural infusate, droperidol appears to significantly reduce nausea and vomiting in ambulatory patients receiving fentanyl and bupivacaine in extended epidural infusions. The possibility that droperidol potentiates analgesic effects could not be evaluated.


PMID: 8537696

Other references

A.J.M.Kay; K.A.W.aler, 2006: The electric field in northern England and southern Scotland; implications for geomagnetically induced currents. Geophysical Journal International 167(2): 613-625

Monlux, D.J.; Finne, H.A.; Stephens, M.B., 2011: Color blindness and military fitness for duty: a new look at old standards. Military Medicine 175(2): 84-85

Farinas E.; Cantor J.O.; Mandl I.; Turino G.M., 1985: Glycosaminoglycan synthesis in amiodarone induced pulmonary fibrosis. Federation Proceedings 44(3): 748

Schwarz, W., 1964: The Endoplasmatic Reticulum In The Liver Cells Of Human Embryos. Verhandlungen der Anatomischen Gesellschaft 58: 184-194

Kojima, M.; Nakano, Y., 1978: A simple quantitative determination of ethanol in drugs by gas chromatography using the headspace analytical technique. III. Toiletries. Yakugaku Zasshi 98(10): 1427-1431

Houssay, B.A.; Marenzi, A.D.; Mazzocco, Y.P., 1926: Action of snake venoms in vivo on blood gases, reaction and salts. An experimental study showing that the venom of Lachesia alternatus, L. neuwiedii and Naja tripudians injected intravenously into a dog produces decrease in red cells, hemoglobin and O2; marked increase of the inorganic K and P of the plasma; slig...

Bugalho, P.; Viana-Baptista, M.; Jordão, C.; Secca, M.F.; Ferro, J.M., 2007: Age-related white matter lesions are associated with reduction of the apparent diffusion coefficient in the cerebellum. Cerebellar apparent diffusion coefficient (ADC) was found to be increased after acute cerebral hemispheric stroke. There are no data on cerebellar ADC changes in patients with chronic, age-related white matter lesions (ARWML). We aimed to determin...

Fedorov, M.V.; Pantosh, D., 1958: The growth intensity of the plant and the number of rhizosphere bacteria developing on its root surface.. In pot experiments with wheat in sod-podzolized soil with and without NPK, in chernozem and in water culture the dry-matter yield of the wheat shoot and the total number of rhizosphere bacteria increased from tillering to ear formation and then gr...

Jarosz, K.; Kubisa, B.; Andrzejewska, A.; Mrówczyńska, K.; Hamerlak, Z.; Bartkowska-Śniatkowska, A., 2017: Adverse outcomes after percutaneous dilatational tracheostomy versus surgical tracheostomy in intensive care patients: case series and literature review. Tracheostomy is a routinely done procedure in the setting of intensive care unit (ICU) in patients requiring prolonged mechanical ventilation. There are two ways of making a tracheostomy: an open surgical tracheostomy and percutaneous dilatational...

Zhang, Y.; Gao, Y.; Chen, J.; Ma, L.; Liu, L.; Wang, X.; Fan, Z., 2016: Effect of a paclitaxel-eluting metallic stent on rabbit esophagus. NlmCategory="UNASSIGNED">The use of self-expanding metallic stents (SEMS) is the current treatment of choice for malignant gastrointestinal obstructions. A paclitaxel-eluting metallic SEMS (PEMS) may have an antitumor effect on esopha...