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Reduction of oxidative stress augments natriuretic effect of furosemide in moderate heart failure

, : Reduction of oxidative stress augments natriuretic effect of furosemide in moderate heart failure. American Heart Journal 145(1): E2-E2

The significance of antioxidant therapy in heart failure has not been fully examined. This study evaluated whether vitamin C has beneficial effects on renal function or augments the renal effects of furosemide in patients with heart failure. There were 2 protocols. In protocol 1, plasma level of thiobarbituric acid-reactive substances (TBARS) and renal function were assessed before and after intravenous infusion of vitamin C or placebo in 8 patients with moderate congestive heart failure (CHF) treated with enalapril. In protocol 2, a randomized crossover study was performed in patients with moderate CHF treated with either an ACE inhibitor (enalapril) (n = 10) or an angiotensin II receptor antagonist (losartan) (n = 9) and in asymptomatic patients with impaired left ventricular function treated with enalapril (n = 8). TBARS and renal function were assessed before and after intravenous infusion of furosemide alone, coinfusion of furosemide with placebo and vitamin C, or coinfusion of furosemide with vitamin C and a kallikrein inhibitor (nafamostat mesilate). In protocol 1, although vitamin C reduced TBARS, it did not affect renal function. In protocol 2, TBARS was higher in patients with moderate CHF than in asymptomatic patients. Vitamin C augmented natriuretic effect of furosemide (from 179 +/- 98 to 192 +/- 104 micromol/min, P <.01) only in patients with moderate CHF treated with enalapril but not in the other 2 groups. Nafamostat mesilate prevented this augmentation. In patients with CHF treated with enalapril, counteraction of the increased oxidative stress by vitamin C may contribute to the augmented natriuretic effect of furosemide through the renal kinin-nitric oxide pathway.


PMID: 12514674

DOI: 10.1067/mhj.2003.42

Other references

Anonymous, 2013: Lupus eritematoso sist mico II. El lupus eritematoso sist mico es una enfermedad compleja, con un espectro cl nico ampl simo y, por tanto, con un tratamiento que ha de cumplir requisitos dif ciles: prevenir las reactivaciones y complicaciones a medio y largo plazo, controlar la...

Donati, Dino, 1934: Hypophysis and basal metabolism. A slight but persistent rise in basal metabolism (BM) in 2 hypophysectomized dogs is attributed to increased activity of the dogs. In 4 normal dogs subcut. injection of extract of whote hypophysis nearly doubled the BM for ca. 1 hr. after treatmen...

Kawahara, E.; Wakanatsu, T.; Miura, Y., 1977: Studies on a forage crop Silphium perfoliatum. 2. On the germination of seed. Presence or absence of light had no effect on germination seeds of S. perfoliatum, and no hard seeds were found. Opt. temp. for germination was 22-25 deg C; there were no differences in germination rate between constant and alternating temp. seedb...

Sandler, R.S.; Cummings, M.S.; Keku, T.O.; Terse, A.; Mehta, N., 2000: Disposable versus reusable biopsy forceps for colorectal epithelial cell proliferation in humans. The performance of various measures of rectal mucosal proliferation has been evaluated in the literature, but the performance of the forceps used to obtain the tissue has received little attention. We used data from two large studies of proliferat...

Scott, D.B., 1955: The electron microscopy of enamel and dentin. Annals of the New York Academy of Sciences 60(5): 575-584

Barton D.W., 1973: Is your recommended dietary allowance safe. New York's Food & Life Sciences Quarterly 6(1): 3-4

Oudjani, C.; Dany, L.; Derome, M.; Bataille, J., 2015: Social representations of contention in children: of the viewpoint of pediatric professionals. This study is part of a current context raising questions on restraint practices in healthcare at the national and international level. It examines how social representations of restraint organize and shape the discourse of professionals within th...

Kharitonov, L.G., 1983: Complications of postoperative reflux esophagitis. Grudnaia Khirurgiia: 48-52

Yang; Anderson, 1986: Specific heat of melanin at temperatures below 3 K. Physical Review. B, Condensed Matter 34(4): 2942-2944

Tschirhart E.; Bertrand C.; Landry Y., 1987: Partial characterization of the airway epithelium dependent relaxant factor aedrf in guinea pig trachea. International Archives of Allergy & Applied Immunology 83(SUPPL 1): 33