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Regulatory peptide receptors as molecular targets for cancer diagnosis and therapy

, : Regulatory peptide receptors as molecular targets for cancer diagnosis and therapy. Quarterly Journal of Nuclear Medicine 41(2): 63-70

Regulatory peptides are small, readily diffusable and potent natural substances with a wide spectrum of receptor-mediated actions in humans. High affinity receptors for regulatory peptides such as somatostatin, substance P, vasoactive intestinal peptides, and cholecystokinin can be overexpressed in several human diseases, in particular in neoplasms, and represent therefore new molecular targets for cancer diagnosis and therapy. The availability of suitable regulatory peptide radioligands, which can be labeled with radioactive iodine or indium, makes peptide receptor scintigraphy a particularly useful new in vivo diagnostic tool, as seen with the example of somatostatin receptor scintigraphy (Octreoscan). The present article reviews the current in vitro data on regulatory peptide receptor expression in normal and diseased tissues, which represent the basis for the in vivo application of these molecules in nuclear medicine.


PMID: 9203845

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Opitz, A., 1993: Menuing seafood. This article describes the use of quality products and creativity to promote seafood menus for school meals.

Das, D.; Chatti, V.; Emonet, T.; Holley, S.A., 2017: Patterned Disordered Cell Motion Ensures Vertebral Column Symmetry. The biomechanics of posterior embryonic growth must be dynamically regulated to ensure bilateral symmetry of the spinal column. Throughout vertebrate trunk elongation, motile mesodermal progenitors undergo an order-to-disorder transition via an ep...

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Dreyers, C., 1990: An HIV-positive patient praises and castigates Danish nursing personnel. Interview by Grethe Nielsen. Sygeplejersken 90(8): 6-7, 14

Redeker, N.S.; Ruggiero, J.S.; Hedges, C., 2004: Sleep is related to physical function and emotional well-being after cardiac surgery. Emotional well-being and physical function are important quality-of-life outcomes after cardiac surgery. Alterations in sleep patterns, including sleep deprivation and altered circadian patterning, also are common. The relations among sleep patter...

Lindfield, R., 2014: The value of clinical audit to improve cataract quality. Community Eye Health 27(87): 55-55

Bormann, G.; Holzhausen, H-J.; Helmbold, P.; Marsch, W-Ch., 2004: Nodules of the scalp and body folds. Annales de Dermatologie et de Venereologie 131(5): 499-502

Huang, W., 2016: Oxide Nanocrystal Model Catalysts. Model catalysts with uniform and well-defined surface structures have been extensively employed to explore structure-property relationships of powder catalysts. Traditional oxide model catalysts are based on oxide single crystals and single crysta...

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Evans, P., 1942: Hospital diarrhoea. Archives of Disease in Childhood 17(91): 130-135