geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Renin-angiotensin-aldosterone system and heart failure: therapeutic aspects


, : Renin-angiotensin-aldosterone system and heart failure: therapeutic aspects. Therapie 53(3): 285-289

Renin, angiotensin II and aldosterone levels are elevated in congestive heart failure, especially when diuretics are introduced. This activation is clearly deleterious by elevating myocardial workload and is related to prognosis of heart failure. The link between hormonal activation and prognosis is causal, as hormonal inhibition by converting enzyme inhibitors improves heart failure prognosis. Angiotensin II and aldosterone appears to be toxic for the myocardium. The results of the trial conducted with angiotensin II antagonist losartan confirm data derived from converting-enzyme-inhibitors trials. The exact role of aldosterone is currently being evaluated in the RALES programme.

US$29.90

PMID: 9773128


Other references

Misra, A.; Tyagi, P.K.; Rai, P.; Misra, D.S., 2007: FTIR spectroscopy of multiwalled carbon nanotubes: a simple approach to study the nitrogen doping. The nitrogen doped multiwalled carbon nanotubes (MWNTs) were synthesized by microwave plasma chemical vapor deposition (MPCVD) technique. In this paper, we report the results of FTIR, Raman, and TGA studies to confirm the presence of N-doping insi...

Alkan, I.; Simsek, F.; Haklar, G.; Kervancioglu, E.; Ozveri, H.; Yalcin, S.; Akdas, A., 1997: Reactive oxygen species production by the spermatozoa of patients with idiopathic infertility: Relationship to seminal plasma antioxidants. Purpose: We attempted to determine reactive oxygen species production by the spermatozoa of patients with idiopathic infertility and healthy donors, and observe whether increased production was due to decreased seminal plasma reactive oxygen speci...

Rastorgueva, Eia, 1971: Annual dynamics of the water regime of certain tree species in the steppe zones of the Autonomous Region Khakass. Fiziologo Biokhimicheskie Osobennosti Drevesnykh Rastenii Sibiri: 7-84

Shvar'-Ova, Nia, 1980: Cinnamomophyllum marginatum Kola. Ukrains'kyi botanichnyi zhurnal7(3): 81-83

Tabachnick, W.J., 1991: Evolutionary relationships among California serogroup viruses (Bunyaviridae) and Aedes mosquitoes (Diptera: Culicidae). With reference to the paper by B.F. Eldridge (1990) [see Journal of Medical Entomology, 27: 738-750], the author discusses coevolution and congruence in vector arthropod-arbovirus interactions, to which Dr. Eldridge replies.

Scarpignato C.; Manfredi G.; Tirelli F.; Bertaccini G., 1984: Inhibition of gastric acid secretion by mifentidine in the cat. Journal de Pharmacologie (Paris) 15(4): 535

Niu, C.; Jin, H.; Li, M.; Zhu, S.; Zhou, L.; Jin, F.; Zhou, Y.; Xu, D.; Xu, J.; Zhao, L.; Hao, S.; Li, W.; Cui, J., 2016: Low-dose bortezomib increases the expression of NKG2D and DNAM-1 ligands and enhances induced NK and γδ T cell-mediated lysis in multiple myeloma. Multiple myeloma (MM) is an incurable hematological malignancy, although bortezomib has markedly improved its outcomes. Growing clinical evidence indicates that enhancing induced natural killer (NK) or γδ T cells for infusion is useful in the tr...

Pouget P., 1993: The relationship between rainfall, piezometry and displacements in a natural unstable slope. Revue Francaise de Geotechnique 64: 57-61

Yu, B.; O'Toole, S.A.; Trent, R.J., 2016: Somatic DNA mutation analysis in targeted therapy of solid tumours. Cancer is a disease of the genome with diverse aetiologies including the accumulation of acquired mutations throughout the genome. There has been a flood of knowledge improving our understanding of the biology and molecular genetics of melanoma, l...

Safronov, Ai, 1977: Construction machinery produced by International Harvester. Gidrotekhnika i melioratsiia: 7 107-114