geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Research involving persons with cognitive impairments: results of a survey of Alzheimer disease research centers in the United States


, : Research involving persons with cognitive impairments: results of a survey of Alzheimer disease research centers in the United States. Alzheimer Disease and Associated Disorders 14(1): 20-27

Research involving persons with cognitive impairments presents ethical and practical challenges, including how to obtain valid informed consent. We asked the directors of the 29 U.S. research centers funded by the National Institute on Aging as "Alzheimer Disease Centers" to provide us with policies or guidelines used in their centers or associated institutions with regard to research involving cognitively impaired subjects. Twenty-four of the 29 centers (83%) responded. Five institutions (21%) had authored their own institutional policies, seven (29%) used guidelines issued by the Department of Health and Human Service's Office for Protection from Research Risks, and 12 (50%) had no policy or guidelines. The five institutional policies addressed a variety of issues, including obtaining consent from cognitively impaired subjects or their authorized representatives, subjects' assent to research participation, and guidance concerning determination of subjects' intellectual capacity. A well-written policy on the protection of cognitively impaired research subjects is one way a research institution demonstrates that it gives serious attention to the rights and welfare of these vulnerable persons. We recommend that all institutions conducting such research author written policies articulating appropriate safeguards for these vulnerable subjects. To promote the protection of cognitively impaired subjects, federal agencies and other funding groups may want to consider requiring written institutional policies as one condition of receiving funds to conduct such research.

US$29.90

PMID: 10718201


Other references

Ryo R.; Adachi M.; Sugano W.; Yasunaga M.; Yoshida A.; Jikai J.; Saigo K.; Yamaguchi N.; Akita H.; E.A., 1991: Platelet factor 4 messenger rna expression in cells from a patient with megakaryoblastic crisis of chronic myelogenous leukemia. A 61-year-old man with Philadelphia chromosome-positive chronic myelogenous leukemia developed megakaryoblastic leukemia. In the blast phase, his blast cells showed undifferentiated megakaryoblastic characteristics with no .alpha.-granules or dema...

Zalta, E., 1993: Provider selection standards as a quality indicator. There are many lessons that PPOs and their clients have learned during the past decade. Data are essential. Few claims administrators have invested the capital or resources to capture other than minimal data--many capturing only the elements requi...

Ungureanu, C.M.nciuna, V.I.rdache, A.F.erlinger, U., 1982: Immunoprophylaxis of lung diseases in young cattle. Lucrarile Institutului de Cercetari Veterinare si Biopreparate "Pasteur"6(16): 25-31

Chew, M-Hoe.; Tan, K-Kan.; Lee, C-Wei., 2010: An unconscious patient with a ruptured pseudoaneurysm: clues to suggest intravenous drug abuse. Anz Journal of Surgery 80(5): 379-379

B.E.H.bbs; A.O.d, 1989: Numerical simulation of shear band formation in a frictional-dilational material. Archive of Applied Mechanics 59(3): 209-220

Maccormac, H., 1934: Pigmentary Eruption on Leg. Proceedings of the Royal Society of Medicine 27(8): 1031-1031

Laumonier, Y.; Purnajaya., 1987: The use of ecological vegetation maps in conservation and management of endangered plants and animals. BIOTROP Special Publication, 30: 217-224

Leffers, J.; McDermott-Levy, R.; Smith, C.M.; Sattler, B., 2015: Nursing education's response to the 1995 Institute of Medicine Report: Nursing, Health, and the Environment. Nursing Forum 49(4): 214-224

Trusov V.V.; Filimonov M.A., 1981: Tidazin test for the assessment of gastric secretion. Gastric secretion was studied in 27 healthy subjects and 108 patients with gastroduodenal diseases by using tidazin, a new stimulant of H2-receptors. Tidazin is an active physiological stimulant of gastric secretion, capable of activating pepsin p...

Hayem, F., 2002: Periodic fevers. Periodic fever is defined as a series of unexplained febrile episodes, most often starting during childhood. The febrile episodes last usually few days, are of fixed or variable duration, and regress spontaneously, the intervals between episodes b...