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Results of examination in healthy volunteers of rifampicin and isoniazid bioavailability from Polish two-drug combination capsules of rifamazid used for tuberculosis treatment

, : Results of examination in healthy volunteers of rifampicin and isoniazid bioavailability from Polish two-drug combination capsules of rifamazid used for tuberculosis treatment. Pneumonologia i Alergologia Polska 66(3-4): 198-206

Purpose of the study was the examination of the relative bioavailability of rifampicin and isoniazid from Rifamazid (fixed-dose combination) and bioavailability of each drug in free simultaneous combination. The study was carried out as an open randomized cross-over study comprising 16 healthy volunteers for study of rifampicin and 15 healthy volunteers (slow acetylators) for isoniazid. The results have shown, that the pattern of absorption, elimination, plasma concentrations and pharmacokinetics parameters were found similar after administration of the drugs in free and in fixed combination.


PMID: 9857665

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