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Risk of gallstone disease is associated with serum level of alpha-1-acid glycoprotein

, : Risk of gallstone disease is associated with serum level of alpha-1-acid glycoprotein. Epidemiology 10(6): 764-766

We explored the association between serum level of alpha-1-acid glycoprotein (AGP, an acute phase protein) and the risk of gallstones. AGP was determined in stored serum samples from a case-control study (cases: 113 patients who underwent cholecystectomy for gallstone disease; controls: 184 surgery patients screened by ultrasound, showing no gallstones). Serum AGP correlated negatively with HDL-cholesterol and positively with triglycerides. Presence of gallstones was positively associated with serum AGP, more strongly so for cholesterol gallstones than for pigment gallstones, but not differently between solitary and multiple cholesterol stones. Asymptomatic gallstones (13 surgery patients with gallstones found by screening) were also associated with serum AGP levels. A causal role of elevation of serum AGP (or underlying immune activation) in gallstone formation is discussed.


PMID: 10535793

Other references

Colan S.D.; Sanders S.P., 1985: Depressed myocardial contractility in infants with ventricular septal defects. American Heart Association Monograph (114): III-114

Verbeek J.W., 1990: Late Quaternary calcareous nannoplankton biostratigraphy for the northern Atlantic Ocean. Mededelingen Rijks Geologische Dienst: , Pages 13-33. 1990.

Suh, S.; Schultheiss, T.E., 2013: Distance-to-agreement investigation of Tomotherapy's bony anatomy-based autoregistration and planning target volume contour-based optimization. To compare Tomotherapy's megavoltage computed tomography bony anatomy autoregistration with the best achievable registration, assuming no deformation and perfect knowledge of planning target volume (PTV) location. Distance-to-agreement (DTA)...

McIvor, J.G., 2002: Pastures. This paper discusses pastures management through maintaining large tussock grasses, limiting intensive land uses, and managing a variety of species.

Montgomery, D.R., 2007: Soil erosion and agricultural sustainability. Data drawn from a global compilation of studies quantitatively confirm the long-articulated contention that erosion rates from conventionally plowed agricultural fields average 1-2 orders of magnitude greater than rates of soil production, erosion...

Krasheninnikov, I.A.; Komar, A.A.; Adzhubeĭ, I.A., 1989: Frequency of using codons in mRNA and coding of the domain structure of proteins. Doklady Akademii Nauk SSSR 305(4): 1006-1012

Ghilchik, M.W.; Morris, A.S., 1971: Small-vessel disease in patients with abnormal insulin secretion: a new concept. British Journal of Surgery 58(11): 870-870

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