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Second neoplasms following high-dose chemotherapy and autologous stem cell transplantation for malignant lymphomas: a report of six cases in a cohort of 171 patients from a single institution

, : Second neoplasms following high-dose chemotherapy and autologous stem cell transplantation for malignant lymphomas: a report of six cases in a cohort of 171 patients from a single institution. Leukemia & Lymphoma 31(1-2): 187-194

High dose chemotherapy with autologous stem cell transplantation (ASCT) is increasingly used in the treatment of patients with lymphoma. As previously shown with conventional treatments, second neoplasms are emerging as a long term complication of the procedure. In this study, we investigate the incidence of second neoplasm in a cohort of 171 patients treated with BEAM or BEAC regimens for Hodgkin's disease (n = 62) and non-Hodgkin's lymphomas (n = 109) followed up for a median of 52 months post ASCT. Six patients developed six second malignancies 12 to 105 months after ASCT: fibrolamellar carcinoma of the liver, malignant fibrous histiocytoma, pancreatic carcinoma, squamous cell carcinoma of the lung, invasive carcinoma of the vulva and acute myelogenous leukemia. The cumulative actuarial risk for developing second malignancy is 16.7% (95% confidence interval: 5.9-39.3%) 13 years after transplant. The age-adjusted incidence of cancer in the study group is 4.1 times higher than that of primary cancer in the general population. These data confirm that ASCT recipients are at increased risk of later malignancies. This complication adds significant morbidity and mortality to the transplant process and therefore, needs to be taken into account in long term evaluation of new strategies which involve early intensification in the treatment of lymphomas.


PMID: 9720728

DOI: 10.3109/10428199809057598

Other references

Filippini, A.; Masella, A.; Tomasso, S.; Sampalmieri, G.; Giordano, R., 1979: Lipomas of the parotid region. Case reports and interpretations. Annali Italiani di Chirurgia 51(5): 509-515

Bertetti, D.; Gullino, M.L.dovica; Garibaldi, A., 2007: Susceptibility of evergreen azalea cultivars to anthracnose caused by Colletotrichum acutatum. Colletotrichum acutatum is the causal agent of anthracnose on azalea (Rhododendron azalea). This disease was observed in Fall 2002 on 'Palestrina' azalea in Italy. Severe outbreaks of this disease were recently observed on several cultiv...

Kusayama, T.; Yamazaki, J.; Nagao, T., 1996: Flow dependence of nitric oxide-mediated pressure change in rat mesenteric beds with different tonus. To investigate the flow-dependent contribution of basally released nitric oxide (NO) to vascular perfusion pressure, we compared the effects of a NO synthesis inhibitor on the pressure changes in some models of rate mesenteric vascular beds. Spont...

Mayer, T.G., 1987: Assessment of lumbar function. There are several problems associated with the conventional assessment of disability in the low back, and none are more disturbing to the clinician than the absence of visual feedback to measure physical capacity. This problem forces an assessment...

Ezhov B.V., 1987: Existence of Cenozoic island arc systems in Kamchatka. The possibility of interpreting the history of the Kamchatka geologic evolution in the Cenozoic as the epoch of forming the subparallel diverse-age island-arc systems is substantiated.

Fleckenstein Gruen G., 1975: Further studies on the neutralization of glycoside induced contractures of coronary smooth muscle by calcium antagonistic compounds verapamil d 600 prenylamine nifedipine fendiline or nitrites. Naunyn Schmiedeberg'S Archives Of Pharmacologyuppl: R38

Perex, G.J.; Toro, L.; Erulkar, S.D.; Stefani, E., 1993: Characterization of large-conductance, calcium-activated potassium channels from human myometrium. Objectives: The purpose of our study was to detect and characterize potassium channels in the plasma membrane of smooth muscle cells from human myometrium. Study Design: Plasma membrane vesicles were incorporated into lipid bilayers to record sing...

Azaaro, A.J.; Ziance, R.J.; Rutledge, C.O., 1974: The importance of neuronal uptake of amines for amphetamine induced release of tritiated norepinephrine from isolated brain tissue. Journal of Pharmacology and Experimental Therapeutics 189(1): 110-118

Anonymous, 2005: A strategy for developing an HIV vaccine. Plos Medicine 2(1): E35-E35

Ponomareva, A.G.; Tsarev, V.N.; Ushakov, R.V.; Ushakova, T.V.; Grineva, G.P., 1991: Effects of antibiotics and anti-bacterial components of preparations for local treatment of suppurative wounds on pathogens of odonto- genic infections. The results of identification and sensitivity assay of 156 strains of pathogens causing odontogenic infections are presented. In the sensitivity assay antibacterial drugs were used. 42.3 percent of the strains were obligate anaerobes belonging to...