geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Serum anti-p53 autoantibodies from patients with idiopathic pulmonary fibrosis associated with lung cancer


, : Serum anti-p53 autoantibodies from patients with idiopathic pulmonary fibrosis associated with lung cancer. Respiratory Medicine 94(11): 1085-1091

Mutations of the tumour suppressor gene p53 lead to accumulation of the mutated p53 protein and subsequent production of antoantibodies against p53 proteins, which are also detected in lung cancer. Lung cancer is frequently associated with idiopathic pulmonary fibrosis (IPF). Therefore, we hypothesized that there might be a relationship between the p53 mutation and high prevalence of lung cancer in IPF. To test this hypothesis, we measured serum p53 antibody levels by an ELISA in various lung diseases including lung cancer (n=98), IPF (n=46; with lung cancer, n=14 and without lung cancer, n=32), pulmonary emphysema (PE, n=23) and healthy controls (HC, n=93). The median values of the serum anti-p53 antibody in each group were 8.78, 9.18, 8.08 and 4.95 for patients with lung cancer, IPF with lung cancer, IPF without lung cancer and PE, respectively, and 2.2 for the healthy control group. The groups of IPF (with and without lung cancer) showed a similar level of median values to the lung cancer group and a tendency for a higher level than the PE group. When the cut-off value was set at 7.7 according to the 95% specificity level for normal control, the incidence of positive anti-p53 antibody was significantly higher in lung cancer (61.2%), IPF with lung cancer (57.1%) and IPF without lung cancer (53.1%) than PE (21.7%). These results suggest that p53 mutations occur frequently and substantially in IPF, resulting in a high prevalence of lung cancer.

US$19.90

PMID: 11127496

DOI: 10.1053/rmed.2000.0917


Other references

Nur, N., 1985: Increased reproductive success with age in the California gull: due to increased effort or improvement of skill?. Oikos, 433: 407-408

Schiess, M.C.; Poindexter, B.J.; Brown, B.S.; Bick, R.J., 2005: The effects of CGRP on calcium transients of dedifferentiating cultured adult rat cardiomyocytes compared to non-cultured adult cardiomyocytes: possible protective and deleterious results in cardiac function. CGRP has potent cardiovascular effects but its role in heart failure is unclear. Effects of CGRP on calcium concentrations in fresh adult rat cardiomyocytes, cultured adult cardiomyocytes and neonatal cardiomyocytes were determined by real time fl...

Beyer C.; Fiedler H.; Wohlrab W.; Wozniak K D., 1986: Comparative investigations of the excretion of 5 s cysteinyldopa and indole melanogens into urine. The excretion of 5-S-cysteinyldopa and indole melanogen was investigated in 36 melanoma patients and 12 controls. In essence, the excretion of 5-S-cysteinyldopa was increased in tumor stage II and III (classified due to Sylven) whereas the indole...

Chugunkina, M.I., 1964: A Collective Of Communist Work. Zdravookhranenie Belorussii 10: 36-37

Jones, H.E.; Sillito, A.M., 1993: Spatial influences on orientation biases exhibited by dorsal lateral geniculate nucleus cells. Society for Neuroscience Abstracts 19(1-3): 524

Lee, W., L.; Mason, D.; Schreiber, A., D.; Grinstein, S., 2007: Quantitative analysis of membrane remodeling at phagocytic cup. Nascent phagosomes, which are derived from the plasma membrane, acquire microbicidal properties through multiple fusion and fission events collectively known as maturation. Here we show that remodeling of the phagosomal membrane is apparent even...

Blair, E.L.; Keenlyside, R.M.; Newell, D.J.; Reed, J.D.; Richardson, D.D., 1968: Assay of gastrin by means of its gastric acid stimulating activity. 1. A method is described for the bio-assay of gastrin activity in the anaesthetized cat, based on the acid stimulating activity of gastrin.2. A ;gastrin' of unknown potency can be assayed in terms of a stable Standard Gastrin Extract or of Sy...

Ratib, O.; Henze, E.; Hoffman, E.; Phelps, M.E.; Schelbert, H.R., 1982: Performance of the rotating slant-hole collimator for the detection of myocardial perfusion abnormalities. To determine the usefulness of the rotating slant-hole (RSH) collimator, a new imaging device for tomographic myocardial imaging, we evaluated its performance in phantom studies. Perfusion defects of variable size, location, and tracer concentrati...

Anonymous, 1969: The New Jersey Dental Service Plan. Journal of the New Jersey State Dental Society 40(6): 223-233

Mazina, D.; Donneau, A-F.; Mairiaux, P., 2012: Determinants of sickness absence duration after an occupational back injury in the Belgian population. This study aimed at assessing factors associated to the duration of sickness absence after a back injury in the Belgian working population, with a special emphasis on cultural factors. The data were retrieved from the Belgian Fund for Work Acciden...