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Severe amyloidosis with mild multiple myeloma--an unusual course

, : Severe amyloidosis with mild multiple myeloma--an unusual course. Haematologia 30(1): 55-59

Amyloidosis may be primary or myeloma-associated. Skeletal lesions and the percentage of bone marrow plasma cells (<10% in primary, >20% in myeloma) account for the major differences between the two varieties. In the literature there are rare cases of primary amyloidosis presenting without myeloma and followed by development of myelomatous manifestations. Usually, the primary disease (i.e. the myeloma) is advanced, when amyloidosis is diagnosed. We describe a patient who had presented with a severe and progressive systemic amyloidosis and was diagnosed later to have a mild light chain myeloma. Aggressive treatment with melphalan, prednisone and colchicine resulted in a temporary partial remission, followed by a rapid downhill course, and the patient's death. The point of relatively mild myeloma following a rapidly progressive course of advanced amyloidosis is emphasized. Awareness of the possibility of such a combination may lead to early diagnosis, a more aggressive or novel therapeutic approach and, possibly, to a better prognosis.


PMID: 10841327

Other references

Conway, P.J.; Herzog, W., 1991: Changes in walking mechanics associated with wearing an intertrochanteric support belt. This study assesses changes in the mechanics of walking for sacroiliac joint patients when: a) wearing an intertrochanteric support belt, b) wearing an intertrochanteric support belt in a placebo position and c) not wearing a support belt at all....

Amberg, D.C.; Burke, D.J.; Strathern, J.N., 2006: Yeast Vital Stains: Visualizing Vacuoles and Endocytic Compartments with FM4-64. Csh Protocols 2006(1): -

Colotla, V.A.; Bowman, M.L.; Shercliffe, R.J., 2002: Test-retest stability of injured workers' MMPI-2 profiles. Ninety-four workers completed the Minnesota Multiphasic Personality Inventory--2 (MMPI-2) on 2 separate occasions, with an average lag of 21.3 months (SD = 14.1, range = 2-75), within the context of a psychological assessment after suffering an in...

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Foley, T.F.; Mamandras, A.H., 1992: Facial growth in females 14 to 20 years of age. The objective of this study was to determine the magnitude and the direction of postpubertal mandibular and maxillary facial growth in females. The sample consisted of 37 untreated subjects who had Class I skeletal and dental characteristics and w...

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González-Rosende, M.Eugenia.; Olivar, T.; Castillo, E.; Sepúlveda-Arques, Jé., 2008: 2-sulfonyliminodihydropyrimidines: a novel class of analgesic compounds. A series of 2-sulfonyliminodihydropyrimidine derivatives have been synthesized and evaluated in vivo for their antinociceptive and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid. Compounds 6Ab-d and 6Be...

Demoy, M.; Gibaud, S.; Andreux, J.-Paul; Weingarten, C.; Gouritin, B.; Couvreur, P., 1997: Splenic trapping of nanoparticles: Complementary approaches for in situ studies. Purpose. To identify more accurately in the spleen, the areas and the cells where nanoparticulate carriers were taken up from the blood flow, a series of complementary approaches were used. Methods. First, in and ex vivo examination of the whole s...

Ericsson, H.; Erlanson, P.; Tunevall, G.; Wallmark, G., 1953: Determination of chemoresistance of bacteria; principles of technic and evaluation. Svenska Lakartidningen 50(9): 476-481

Lesovoi, Mp, 1979: Factors determining race dominance in the populations of brown rust pathogen of wheat. Mikologiia i fitopatologiia3(2): 131-136