+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Successful treatment of HTLV-1-associated acute adult T-cell leukaemia lymphoma by allogeneic bone marrow transplantation

, : Successful treatment of HTLV-1-associated acute adult T-cell leukaemia lymphoma by allogeneic bone marrow transplantation. British Journal of Haematology 94(4): 713-715

HTLV-1-associated acute adult T-cell leukaemia-lymphoma (ATL) is a highly aggressive malignant disorder with a median survival of 6 months or less. We describe an Afro-Caribbean female with very poor prognosis ATL who underwent chemotherapy with a 4 d infusion schedule of cyclophosphamide, doxorubicin and etoposide, followed by successful allogeneic bone marrow transplantation (BMT) from her HTLV-1-negative histocompatible sister. The patient remains in complete remission 23 months after BMT and has 100% donor haemopoiesis with no evidence of HTLV-1 infection on PCR testing. We suggest that allo-BMT can prolong disease free survival or may even be curative in HTLV patients.


PMID: 8826899

Other references

Das, S.; Das, U.; Michel, D.; Gorecki, D.K.J.; Dimmock, J.R., 2013: Novel 3,5-bis(arylidene)-4-piperidone dimers: potent cytotoxins against colon cancer cells. Two novel series of dimeric 3,5-bis(arylidene)-4-piperidones 7 and 8 were prepared as cytotoxic agents. A specific objective of this study was the discovery of novel compounds displaying potent anti-proliferative activities against colon cancers....

Anonymous, 1990: Science and black churches. Science 249(4968): 568-568

Kahn, Jennifer, 2002: The High-Tech Age of Counter Intelligence. The All Species Foundation, a privately funded initiative, hopes to use modern technology to take all of the world's taxonomic projects and synthesize them into one super-catalog of every living thing on the planet within the next 25 years. H...

Cox, D.; Tinloi, S.F.; Farrimond, J.G., 1988: Investigation of the spontaneous modes of breathing of different ventilators. We investigated six ventilator systems which were designed to allow spontaneous breathing. The time delay between initiation of inspiratory effort and the beginning of inspiratory gas flow was measured, as was the amount of negative (to ambient) p...

Nicolas, G.; Farrow, RA.; Dowse, JD., 1982: Influences de la densite de populations sur le dimorphisme alaire et la morphometrie du Phaulacridium vittattum Sjost. (Acrididae, Cantantopinae). Comptes Rendus de l'Academie des Sciences Serie III Sciences de la Vie, 29410: 429-432

Korol' chuk, V.V.; Nesterov, P.I.; Bryushkova, G.I.; Lizogubova, L.P., 1971: Evaluations of the resistance of local varieties of sugar-beet to Heterodera schachtii. Infestation and sugar content were studied in 37 Russian varieties of sugar-beet grown in soil infested or uninfested with Heterodera schachtii. All varieties became infested, although to widely differing degrees. Reduction of sugar was not propor...

Jonas, J.B., 2004: Optic nerve grey crescent. British Journal of Ophthalmology 89(1): 3-3

Fox, GQ.; Kriebel, ME.; Kotting, D., 1988: Synaptic vesicle classes in Torpedo and skate electric organ and muscle. NATO ASI Series Series H Cell Biology, 21: 83-95

Chen, L.S.iuh; Kompella, U.; Lee, V.H.L., 1992: Chronopharmacokinetics of ocularly applied pilocarpine in the pigmented rabbit. Pharmaceutical Research (New York) 9(10 SUPPL ): S269

Ahl, J.; Melander, E.; Odenholt, I.; Tvetman, L.; Thörnblad, T.; Riesbeck, K.; Ringberg, Håkan., 2015: Prevalence of penicillin-non-susceptible Streptococcus pneumoniae in children in day-care centres subjected to an intervention to prevent dispersion. The aim of this study was to evaluate the day-care interventions implemented in southern Sweden to restrict the dispersion of penicillin-non-susceptible pneumococci with a minimum inhibitory concentration of penicillin G of at least 0.5 mg/l (PNSP...