+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Synthesis and evaluation of pyrazolignans. A new class of cytotoxic agents

, : Synthesis and evaluation of pyrazolignans. A new class of cytotoxic agents. Bioorganic & Medicinal Chemistry 3(9): 1203-1210

A series of fused pyrazole derivatives of cyclolignans have been prepared through simple chemical routes and evaluated for their cytotoxic activities in culture cells of P-388 murine leukemia, A-549 lung carcinoma and HT-29 colon carcinoma. Despite the lack of the lactone moiety in their structures, they show IC50 values at microM levels.


PMID: 8564411

Other references

Arndt, S.K.; Livesley, S.J.; Merchant, A.; Bleby, T.M.; Grierson, P.F., 2008: Quercitol and osmotic adaptation of field-grown Eucalyptus under seasonal drought stress. This study investigated the role of quercitol in osmotic adjustment in field-grown Eucalyptus astringens Maiden subject to seasonal drought stress over the course of 1 year. The trees grew in a native woodland and a farm plantation in the semi-ar...

Mukherjee S.R.; Pal A.K., 1969: Feeding effect of vicia d species on the serum glutamic oxalacetic trans aminase activity of pigs. Indian Journal of Animal Health 8(2): 141-145

Peppel, K.; Huang, X.; Jacobson, A.; Freedman, N.J., 1999: G protein-coupled receptor kinases attenuate smooth muscle cell mitogenesis and chemotaxis. Circulation 100(18 SUPPL ): I 771, Nov 2

Boughton, D.A.; Smith, E.R.; O'neill, R.V., 1999: Regional vulnerability: A conceptual framework. Regional vulnerability assessment, or ReVA, is an approach to place-based ecological risk assessment that is currently under development by the Office of Research and Development of the U.S. Environmental Protection Agency (EPA). The assessment is...

Gao Yuan; Liu Zhaojun, 1995: Dynamical implications of earthquake modeling using stochastic cellular automata. Earthquake Research in China = Zhongquo Dizhen 9(4): 379-385

Congdon, K.L.; Reya, T., 2008: Divide and conquer: how asymmetric division shapes cell fate in the hematopoietic system. A fundamental mechanism by which cells can give rise to daughters with different fates is via asymmetric division. During asymmetric division, a mother cell generates daughter cells that go on to adopt different fates because of differential segre...

Maltau, J.M., 2001: Hemorrhage in labor. Tidsskrift for den Norske Laegeforening 120(24): 2859-2859

Becquart; Clapp; Rifkin, 1993: Molecular-dynamics simulation of tweed structure and the omega phase in Ni-Al. Physical Review. B, Condensed Matter 48(1): 6-13

Cherubini, C.; Filippi, S.; Nardinocchi, P.; Teresi, L., 2008: An electromechanical model of cardiac tissue: constitutive issues and electrophysiological effects. We present an electromechanical model of myocardium tissue coupling a modified FitzHugh-Nagumo type system, describing the electrical activity of the excitable media, with finite elasticity, endowed with the capability of describing muscle contrac...

Korovin, R.N.; Zelenskii, V.P., 1984: Neoplastic diseases of poultry. One chapter deals with the leukosis-sarcoma complex, another with Marek's disease and a brief final chapter with meat inspection aspects of these diseases.