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Synthesis and evaluation of pyrazolignans. A new class of cytotoxic agents


, : Synthesis and evaluation of pyrazolignans. A new class of cytotoxic agents. Bioorganic & Medicinal Chemistry 3(9): 1203-1210

A series of fused pyrazole derivatives of cyclolignans have been prepared through simple chemical routes and evaluated for their cytotoxic activities in culture cells of P-388 murine leukemia, A-549 lung carcinoma and HT-29 colon carcinoma. Despite the lack of the lactone moiety in their structures, they show IC50 values at microM levels.

US$29.90

PMID: 8564411


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