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Synthesis of sialyl Lewis X mimetics using the Ugi four-component reaction

, : Synthesis of sialyl Lewis X mimetics using the Ugi four-component reaction. Bioorganic & Medicinal Chemistry Letters 8(17): 2333-2338

Application of the Ugi four-component condensation to rapidly synthesize a library of glycopeptide mimics of the tetrasaccharide SLe(x) as inhibitors of E- and P-selectin, and to study the effect of varied functionality in mimics on the inhibition is described.


PMID: 9873537

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