+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

T cell receptor V-gene usage in oral lichen planus; increased frequency of T cell receptors expressing V alpha 2 and V beta 3

, : T cell receptor V-gene usage in oral lichen planus; increased frequency of T cell receptors expressing V alpha 2 and V beta 3. Clinical and Experimental Immunology 98(3): 503-507

In order to analyse the clonality of T cells in the inflammatory infiltrate of oral lichen planus (OLP), mucosal biopsies were obtained from seven patients with manifest disease. The biopsies were stained with MoAbs directed against 11 different T cell receptor (TCR) V-gene families, anti-CD4, anti-CD8 and IL-2 receptor (IL-2R). For comparison, the frequencies of the different TCR V-families were determined in biopsies from five patients with oral candidosis as well as in peripheral blood from three patients with OLP and from six healthy blood donors (HBD). The occurrence of the investigated TCR V-families varied between 0% and 7% in venous blood obtained from both HBD and OLP patients. T lymphocytes expressing the TCR V beta 3 and V alpha 2 in OLP biopsies were, however, detected in frequencies ranging between 18% and 40% of the total fraction of lymphocytes, a consistent finding for all the OLP infiltrates studied. The other nine TCR V-families examined appeared in low frequencies both in biopsies and in peripheral blood. V alpha 2+ and V beta 3+ cells were often localized adjacent to the basal membrane. In contrast, T cells in Candida-induced lesions did not express a biased TCR distribution, and most V-families studied appeared in frequencies of 0-6%. Thus, T lymphocytes in OLP lesions express a substantially higher frequency of TCR V alpha 2 and V beta 3 than expected from the distribution in blood. The clonal expansion of T cells observed in OLP suggests that a superantigen is involved in the pathogenesis of the disease. Whether this superantigen is of exogenous or endogenous origin needs to be investigated.


PMID: 7994913

Other references

Beldi, F.B.lint, J., 1983: Determination of the water absorption and resistance to climate of wood for window frames. 2. Holztechnologie 24(2): 113-116

Gosal, D.; Lynch, T.; Ross, O.A.; Haugarvoll, K.; Farrer, M.J.; Gibson, J.Mark., 2006: Global distribution and reduced penetrance: Lrrk2 R1441C in an Irish Parkinson's disease kindred. Movement Disorders 22(2): 291-292

Tanegashima, K.; Sato-Miyata, Y.; Funakoshi, M.; Nishito, Y.; Aigaki, T.; Hara, T., 2016: Epigenetic regulation of the glucose transporter gene Slc2a1 by β-hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice. NlmCategory="UNASSIGNED">We carried out liquid chromatography-tandem mass spectrometry analysis of metabolites in mice. Those metabolome data showed that hepatic glucose content is reduced, but that brain glucose content is unaffected...

Allen, Ena A., 1937: Tyzzeria perniciosa gen. et sp. nov., a Coceidium from the Small Intestine of the Pekin Duck, Anas domesticus L. describes the life-cycle and pathogenicity of a new coccidium of the duck, which has been named Tyzzeria perniciosa. A key to the genera of the sub-family Cryptosporidiinae is given; the sporulated oocyst of T.p. (measuring 9-10 micro by 10-13 mic...

Slavkin H.C.; Brat V.; Fischer H.; Dorey C.K., 1977: Localization of initial enamel protein secretion during embryonic tooth morphogenesis. Journal of Dental Research 56(SPEC ISSUE A): A135

Jenkins, David R., 1966: Problems of computer applications in medical research. Trans N Y Acad Sci 28(3): 439-447

Thomas, A.S., 1942: Ecological factors and indicator plants in Tropical Africa. "Little is known about indicator plants in the tropics . . . ." but the grazing plants are the most useful group of plant indicators.

Kaiser, E.A.; Heinemeyer, O., 1990: The determination of microbial biomass in mechanically stressed soils. Microbial biomass, measured using the substrate-induced-respiration method, was studied for 12 months in a field experiment on a parabraunerde from loess under sugarbeet-wheat-barley rotation. Eight traffic load treatments were applied ranging fro...

Cooke, W.D.; Dattwyler, R.J., 1990: Spirochetal arthritis, including Lyme disease. Current Opinion in Rheumatology 2(4): 622-627

Renehan, A.G., 2016: Corrigendum to "Techniques and Outcome of Surgery for Locally Advanced and Local Recurrent Rectal Cancer" [Clinical Oncology 28 (2016) 103-115. Clinical Oncology ) 28(8): E68-E68