+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The diagnosis of "mixed" dementia in the Consortium for the Investigation of Vascular Impairment of Cognition (CIVIC)

, : The diagnosis of "mixed" dementia in the Consortium for the Investigation of Vascular Impairment of Cognition (CIVIC). Annals of the New York Academy of Sciences 903: 522-528

If vascular risk factors are risk for Alzheimer's disease (AD), and if "pure" vascular dementia (VaD) is less common than has been thought, what do we make of the diagnosis of mixed dementia? We report characteristics of those with mixed dementia in a prospective, seven center, clinic-based Canadian study. Of 1,008 patients, 372 were diagnosed with AD, 149 with vascular cognitive impairment (VCI) including 76 with mixed AD/VaD, and 82 with other types of dementia. The mean age of patients with mixed AD/VaD was 78.0 +/- 7.6 years; 49% were female. These proportions differed significantly between dementia diagnosis subgroup (p < 0.001) showing a trend which is evident in all comparisons--AD/VaD patients fall in between AD and VaD. Vascular risk factors were present significantly more often in mixed AD/VaD than in AD (p < 0.001). More mixed AD/VaD (20%) than AD patients (4%) had focal signs, compared with 38% of those with vascular dementia and 12% with other types of dementia. Between the initial clinical diagnosis and the final diagnosis (which utilized neuroimaging and neuropsychological data) AD/VaD was the least stable diagnosis. Neuroimaging of ischemic lesions was the most common reason for reassignment from AD to the mixed AD/VaD diagnosis (17 cases). These data suggest that an operational definition of mixed AD/VaD can be proposed on presentation and clinical/radiographic findings, but indifferent to vascular risk factors. The concept of mixed dementia should be extended to include vascular dementia in combination with dementias, other than Alzheimer's disease.


PMID: 10818547

Other references

Giassetti, M.I.; Goissis, M.D.; de Barros, F.; Bruno, A.H.; Assumpção, M.; Visintin, J.A., 2015: Comparison of Diverse Differential Plating Methods to Enrich Bovine Spermatogonial Cells. Spermatogonial stem cells (SSC) have important applications in domestic animal reproduction and advanced biotechnologies. Because differential plating is one of the most common methods used for SSC enrichment, the goal of this study was to compare...

Salomonsson, S.; Jonsson, M.V.; Skarstein, K.; Brokstad, K.A.; Hjelmström, P.; Wahren-Herlenius, M.; Jonsson, R., 2003: Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjögren's syndrome. To investigate functional properties of the germinal center (GC)-like structures observed in salivary glands of patients with Sjögren's syndrome (SS) and to determine the frequency with which such structures develop. Hematoxylin and eosin-st...

Glanc, K., 1980: Royal fern Osmunda regalis in the Notecka Primeval Forest. Chronmy przyrode ojczysta 36(4): 62-66

Althen, F.W. von, 1972: Preliminary guide to hardwood planting in southern Ontario. Reports that hardwoods may be planted successfully in S. Ontario provided that: the planting site has deep, moist (but well-drained) soil; site preparation is intensive, preferably with ploughing and discing of the whole plantation area; healthy s...

Csuk, Ré.; Siewert, B.; Wiemann, J., 2014: A bioassay-driven discovery of an unexpected selenophene and its cytotoxicity. During the reaction of methyl 3β-acetoxy-glycyrrhetinate (1) with SeO2 significant amounts of a cytotoxic hitherto unprecedented triterpenoic selenophene 3 are formed. This compound stops cell proliferation and acts by apoptosis.

Blos, P., 1967: The second individuation process of adolescence. Psychoanalytic Study of the Child 22: 162-186

Cutropia, J.; Bettalemmi, J., 1961: Klippel-Trenaunay syndrome localized in the hand. El Dia Medico 33(Special): 2540-2542

Nagahata, Y.; Azumi, Y.; Kawakita, N.; Wada, T.; Saitoh, Y., 1995: Inhibitory effect of dopamine on gastric motility in rats. Background: There is disagreement with regard to the involvement of dopamine (DA) receptors in gastric motility. The mechanism of the inhibitory effect of DA on rat gastric motility was investigated in association with acetylcholine (Ach) release...

Müller-Fahlbusch, H.; Sone, K., 1982: Preprosthetic psychogogics. Deutsche Zahnarztliche Zeitschrift 37(9): 703-707

Vertrees, J.D., 1975: Observations on Acer circinatum Pursh. propagation. Scions of the dissected-leaf cv. Monroe of A. circinatum were grafted successfully (over 80%) on rootstocks of A. palmatum but not on A. circinatum itself (only 5%). In further investigations on A. circinatum, cuttings showed very poor rooting. La...