geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The use of biothesiometry to detect neuropathy in children and adolescents with IDDM


, : The use of biothesiometry to detect neuropathy in children and adolescents with IDDM. Diabetes Care 20(9): 1448-1453

To develop clinically useful reference ranges for vibration perception thresholds (VPTs), using biothesiometry in children and adolescents and to assess the reliability of the technique to identify subclinical neuropathy in subjects with IDDM at this age and to examine a large population-based sample of pediatric patients. VPTs were measured using a handheld biothesiometer at the medial malleolus and hallux in 232 nondiabetic children and adolescents aged 7-18 years (12.9 +/- 4.2 years) and a population-based sample of 307 young IDDM patients (13.3 +/- 4.6 years of age). The mean of three readings at each site was correlated with height, pubertal status, and age for all subjects and, in addition for the IDDM sample, with the duration of IDDM, ambient blood glucose, and mean HbA1c from diagnosis. Those IDDM subjects found to have elevated VPTs (> 97th percentile), and a control group of patients with IDDM underwent nerve conduction studies to determine the sensitivity and specificity of biothesiometry to detect abnormal neural function in children. Interoperator reliability was assessed in a separate trial in which two operators measured VPTs independently in the same 11 children. In the nondiabetic control subjects, height demonstrated the best correlation with VPT measures, and a reference range was thus established with percentile charts, using mean VPT and height. VPTs were higher in the diabetic sample, compared with the nondiabetic sample (P < 0.05). Of the children, 28 (9.1%) had VPT values > 97th percentile developed from studies of the nondiabetic subjects; of these, 11 were younger than 11 years and 8 were prepubertal. Nerve conduction studies confirmed reduced conduction velocity and prolonged distal latencies in those with abnormal VPTs, compared with normal control subjects and IDDM patients with normal VPTs. Sensitivity of biothesiometry to reflect abnormal nerve function was estimated as 82% and specificity as 75% at this age. Interoperator variation was small (7.25% of total variance). Biothesiometry is a useful noninvasive tool for the detection of subclinical neuropathy in children and adolescents. The use of height-related reference ranges may make screening for neuropathy more feasible in younger patients and allow large-scale longitudiral analysis of its development.

US$29.90

PMID: 9283795


Other references

Amiri, B.M.jazi; Adams, T.E.; Doroshov, S.I.; Moberg, G.P., 1999: Use of mammalian gonadotropin-releasing hormone to characterize pituitary gonadotropin releasing hormone receptors in white sturgeon. Journal of Applied Ichthyology 15(4-5): 318, Sept

McCluskey, F.J., 1983: Music in the operating suite. Natnews 20(9): 33-40

Borlongan, C.V.; Sanberg, P.R., 2002: Neural transplantation in the new millenium. Cell Transplantation 11(6): 615-618

Monotti, M.; Guiducci, M.; Raggi, V.; Antonielli, G.; Archetti, R., 1987: Umbria. Tabulated data on grain yield and related characters are presented for 61 bread wheat varieties and 2 triticale varieties in trials at 4 localities in the Umbria region of Italy. Also given are data on incidence of Puccinia recondita, Erysiphe gra...

Briceno V.; A., 1971: Presence of the potato miner Liriomyza quadrata Malloch (Diptera-Agromyzidae) in the Andean region of Venezuela. Potato leaves collected in the Venezuelan State of Merida in 1970 were found to be infested by larvae of Liriomyza quadrata (Mall.), a leaf-miner not previously recorded from Venezuela. Severe infestations resulted in defoliation and loss of yield...

Sandritter W., 1970: Functional structure of the nucleus. Medizinische Welt (1): 1-10

Yamori, Y.; Horie, R.; Nara, Y.; Kihara, M.; Ikeda, K.; Mano, M.; Fujiwara, K., 1984: Dietary prevention of hypertension in animal models and its applicability to human. Experimental studies in animals and epidemiological studies have suggested that the interaction between genetic and environmental factors is important in hypertension associated with excess salt intake and other dietary factors such as potassium,...

Sinclair, R.G., 2014: The composition of serum phospholipids. Federation Proceedings 6(1 Pt 2): 291-291

Nasir, I.Ahmad.; Riazuddin, S., 2008: In vitro selection for Fusarium wilt resistance in Gladiolus. Cormels pieces of four Fusarium susceptible Gladiolus cultivars (Friendship, Peter Pears, Victor Borge and Novalux) formed friable calli when cultured in vitro on Murashige and Skoog basal medium containing various concentrations of auxin and cyt...

Naruse, I.; Keino, H.; Kawarada, Y., 1994: Antibody against single-stranded DNA detects both programmed cell death and drug-induced apoptosis. Cyclophosphamide induced fragmented nuclei in mouse thymic epithelial cells. Agarose gel electrophoresis showed the fragmentation of the DNA extracted from mouse thymus exposed to cyclophosphamide. The cell death induced by cyclophosphamide was co...