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Therapeutic efficacy of benzoxazinorifamycin KRM-1648 against experimental murine tuberculosis: (1). A study on the efficacy of short course treatment with the intratracheal and intravenous infection model


, : Therapeutic efficacy of benzoxazinorifamycin KRM-1648 against experimental murine tuberculosis: (1). A study on the efficacy of short course treatment with the intratracheal and intravenous infection model. Kekkaku 73(2): 53-64

This study aims to compare in vivo activity of benzoxazinorifamycin KRM-1648 (KRM) with those rifampicin (RFP) and rifabutin (RBT) against experimental murine tuberculosis. Mice were infected with Mycobacterium tuberculosis or M. bovis by the intratracheal (i.t.) or intravenous (i.v.) routes, and treated for 10 days with various doses of each drug starting from the 9th or 11th day after the TB-infection. (A) A rapid test for in vivo evaluation of three rifamycins was conducted by examining the survival days of treated mice infected with 106 cfu of M. bovis Ravenel. Mice treated with KRM exhibited 2.13.7 times longer survival times, in comparison with those treated with RFP or RBT. (B) In the i.t.-model of M. bovis Ravenel infection, three rifamycin derivatives gave "distinctive dose-response curves" in the correlation of dose sizes with the mean survival times or "log10CFU/lungs reductions". (C) In M. tuberculosis Kurono infection models, the ranking of the anti-TB activity of the three rifamycins in each organ was as follows: i.t.-and i.v.-lungs: KRM >> RFP not equal to RBT, i.v.-spleen: KRM not equal to RBT > RFP, i.v.-liver: KRM not equal to RBT > RFP. (D) Based on the results of "log10CFU reduction" in different organs in M. tuberculosis Kurono infection models, "characteristic in vivo activity patterns of each rifamycin" were obtained. (E) The therapeutic efficacy of KRM in lungs was greater than in spleen and liver with any dose. In contrast, RBT exhibited more remarkable in vivo activity in the spleen and liver than in lungs. The prominent in vivo activity of KRM may allow small dose for effective therapy; 1/3 dose or less in comparison with those of RFP or RBT, or intermittent therapy of tuberculosis.

US$29.90

PMID: 9545697


Other references

Cowan, H.E.; Falkinham, J.O.IIi, 2001: A luciferase-based method for assessing chlorine-susceptibility of Mycobacterium avium. A rapid and quantitative assay for the disinfection of the water-borne pathogen, Mycobacterium avium, was developed using firefly luciferase as a reporter gene. There was a correlation between the quantity of light produced and the number of colon...

Podobnikar, T.; Schoener, M.; Jansa, J.; Pfeifer, N., 2009: Spatial analysis of anthropogenic impact on karst geomorphology Slovenia. Environmental Geology (Berlin) 58.2

Benzakin A C.; Schneider I.; Szylman P.; Taitelman U., 1985: Reversible renal tubular dysfunction manifested by potassium loss in organic mercury intoxication. Journal of Toxicology Clinical Toxicology 23(4-6): 473

Kolár, J.; Bek, V.; Janko, L.; Hrubý, J.; Hradil, M., 1969: 87Sr in the examination of bone diseases. Ceskoslovenska Radiologie 23(4): 163-168

Koksal, I.T.; Usta, M.; Orhan, I.; Abbasoglu, S.; Kadioglu, A., 2003: Potential role of reactive oxygen species on testicular pathology associated with infertility. Aim: To investigate the level of malondialdehyde (MDA), a direct indicator of lipid peroxidation-induced injury by reactive oxygen species (ROS), in testicular biopsy specimens from infertile patients. Methods: Levels of MDA were measured in testi...

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Chemeris, N.A.; Fikhte, B.A., 1979: Effect of a deficiency of carbon, nitrogen, phosphorus and magnesium in the growth medium on the mechanical properties of Escherichia coli cell walls. Values of modulus of elasticity of cell walls and strength level of cells Escherichia coli cultivated in the carbon, nitrogen and phosphorus deficient media or incubated in the magnesium-free medium were determined. Elastic modulus of cells grown...

Soreghan Gerilyn S.; Giles Katherine A., 1999: Facies character and stratal responses to accommodation in Pennsylvanian bioherms, western Orogrande Basin, New Mexico. Upper Paleozoic shallow-water (algal) bioherms were sensitive to changes in accommodation, and thus preserve potentially high-resolution records of the (glacio)eustatic and tectonic perturbations that prevailed during late Paleozoic time. Detailed...

Baldessarini, R.J.; Arana, G.W., 1985: Does the dexamethasone suppression test have clinical utility in psychiatry?. The dexamethasone suppression test (DST) has had unprecedented evaluation among biologic tests proposed for application to psychiatric patients. Several techniques for test administration have been devised, including the use of 1 mg of dexamethaso...

Doelken, P.; Abreu, R.; Sahn, S.A.; Mayo, P.H., 2006: Effect of thoracentesis on respiratory mechanics and gas exchange in the patient receiving mechanical ventilation. Background: This study reports the effect of thoracentesis on respiratory mechanics and gas exchange in patients receiving mechanical ventilation.Study design: Prospective.Setting: University hospital.Patients: Eight patient receiving mechanical...