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Time-dependent systolic and diastolic function in mice overexpressing calcineurin


, : Time-dependent systolic and diastolic function in mice overexpressing calcineurin. American Journal of Physiology. Heart and Circulatory Physiology 284(2): H425-H430

Echocardiograms have been assessed only at 56 days in mice overexpressing calcineurin (CN mice). Age-dependent echocardiographic changes were evaluated because the development of sudden death is time dependent. Because cyclosporin A (CsA) reverses hypertrophy in CN mice, its effects on the time course of the development of sudden death and cardiac dysfunction were assessed. In wild-type (WT) mice, the left ventricular (LV) internal end-diastolic dimension (LVIDd) increased and the LV mass index (LVMI) decreased with age. In CN mice, two distinct phases of pathophysiology were found. After 14 days, in CN mice, the LVIDd and LVMI were significantly increased, but sudden death had not occurred. After 28 days, in CN mice, relative dilation of the left ventricle occurred, whereas the LVMI decreased. Sudden death developed during progressive dilation associated with systolic and diastolic dysfunction. CsA treatment reversed hypertrophy in CN mice but did not reverse systolic and diastolic dysfunction and exaggerated sudden death. Sudden cardiac death was associated with systolic and diastolic dysfunction but was not related to isolated cardiac hypertrophy in CN mice.

US$19.90

PMID: 12388248

DOI: 10.1152/ajpheart.00546.2002


Other references

Watts, B.A.IIi; Good, D.W., 1993: Basolateral membrane sodium, hydrogen exchange enhances transepithelial bicarbonate and ammonium absorption in rat medullary thick ascending limb. Journal of the American Society of Nephrology 4(3): 849

Eckardt, M.J.; Parker, E.S.; Noble, E.P.; Pautler, C.P.; Gottschalk, L.A., 1979: Changes in neuropsychological performance during treatment for alcoholism. A battery of 24 neuropsychological tests was administered to drug-free alcoholic inpatients (n = 91) within 7 days of their last drink and again 17 days later. Comparisons between this group and a nonalcoholic group of medical inpatients (n = 20)...

Krzywicki, H.J.; Chinn, K.S.K., 1966: Body composition of a military population, Fort Carson, 1963. 1. Body density, fat and potassium40. (U.S. Army Med. Res. Nutrit. Lab. Fitzsimons Gen. Hosp., Denver, Colorado. Rep. No. 296). The aim of this series of studies was the selection of methods for estimating water, fat, protein and mineral in the human body, to provide a measure of active tissue mass. Body sp. gr. was calculated from body volume measured by water displacemen...

Anonymous, 1954: Commonwealth of Australia. Twenty-ninth annual report of Australian Dairy Produce Board for the year 1953-54. The report contains statistical data on the production and utilization of milk in Australia during 1953-54, on the export trade in Australian dairy products, and on world production and trade in dairy products.

Panzer, S.; Wilde, H.; Shea, C.H., 2006: Learning of similar complex movement sequences: proactive and retroactive effects on learning. The authors used an interference paradigm to determine the extent to which the learning of 2 similar movement sequences influences the learning of each other. Participants (N = 30) produced the sequences by moving a lever with their right arm and...

Hazard, R.; Vaille, C., 1936: Effect of the magnesium ion on blood sugar in the rabbit. MgCl2, administered subcutaneously to rabbits in doses of 0.06-1.00 g. per kg., increased the sugar content of the blood, although the extent of the increase was not proportional to the magnitude of the dose. Under the influence of injections of s...

Darvall, W.L., 2010: Successful resuscitation after drowning in a home swimming pool. Medical Journal of Australia 191(11-12): 694-694

Magie, R.O., 1954: Gladiolus corm treatments in the control of Fusarium rot. In field experiments conducted in Florida on the control of gladiolus corm rot (Fusarium oxysporum f. gladioli) chemotherapeutants and antibiotics were applied to naturally infected Picardy corms and cormlets by methods designed to force the fungi...

Dua, J.; Chessa, M.; Piazza, L.; Negura, D.; Micheletti, A.; Bussadori, C.; Butera, G.; Carminati, M., 2010: Initial experience with the new Amplatzer Duct Occluder II. Different devices are used for transcatheter occlusion of patent ductus arteriosus (PDA), each with its own limitations and complications. We report our initial single-center experience with the new Amplatzer Duct Occluder II (ADO II), which has b...

Aisen, A.M.; Martel, W.; Braunstein, E.M.; McMillin, K.I.; Phillips, W.A.; Kling, T.F., 1986: MRI and CT evaluation of primary bone and soft-tissue tumors. Twenty-six patients with primary tumors of bone or somatic soft tissues underwent both magnetic resonance imaging (MRI) and computed tomography (CT); 15 of the patients had radionuclide bone scans as well. Only in a minority of cases did these tom...