geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Total synthesis and stereochemistry of cytoblastin


, : Total synthesis and stereochemistry of cytoblastin. Bioorganic & Medicinal Chemistry 6(8): 1243-1254

The first total synthesis and stereochemical assignment of cytoblastin were reported. Key steps included the palladium-mediated coupling of N-SEM-7-bromoindolactam V ((-)-11) with allylstannane c-13, and osmium tetroxide-mediated dihydroxylation of 14, both of which were stereoselective. The stereochemistry of cytoblastin was determined as 1A via spectroscopic analysis of the pentacyclic derivative 21 of cytoblastin. A connection was then made between the stereochemistry so elucidated and the Kishi/Rando hypothesis for the structural correlation between (S)-1,2-diacylglycerol and tumor promoters for the process of protein kinase C activation.

US$29.90

PMID: 9784866


Other references

Schubart, O., 1931: Neue markische Diplopoden. Sitzungsberichte der Gesellschaft Naturforschender Freunde Berl Jahrg, 19304-7: 137-142

Wittung, P.; Kajanus, J.; Kubista, M.; Malmstrom, B.G., 1994: Absorption flattening in the optical spectra of liposome-entrapped substances. Measuring optical spectra of chromophore molecules entrapped in liposomes can lead to considerable distortion because of absorption flattening. This phenomenon is analyzed theoretically, and it is shown that the deviation from the Beer-Lambert law...

Ozçelik, S.; Kengeç, Lütfü.; Celiksöz, A.; Değerli, S.; Ataş, A.Duran.; Poyraz, O., 2008: Cystic echinococcosis: a study of consciousness and creating awareness. Study was started in November 2005 and education practices and other activities have been realized between the dates of December 2005 and 5 January 2006. A wide group has been chosen from the students who are at the level of primary and secondary...

Kaiura, Nn, 1975: Ecological and morphological characteristic of Senecio cannabifolius Less. Biulleten' 7 76-81

Smith James Ward; Thomas Harold E.; Trudell Laurence G., 1968: Geologic factors affecting density logs in oil shale. Two major geologic factors adversely affecting oil-yield estimations from density logs in Colorado's Green River Formation oil shale are examined. Crystalline nahcolite (NaHCO (sub 3) ) and cavities left after nahcolite solution are seen by t...

Gorell, H.A.; Cyr, D.R.; Wang, K.Y.; Greer, B.E., 1989: Rectosigmoid endometriosis. Diagnosis using endovaginal sonography. Journal of Ultrasound in Medicine 8(8): 459-461

Walker P.H.; Ruhe R.V., 1968: Hillslope models and soil formation; 2, Closed systems. Areas of closed drainage, where products of erosion remain in the toeslope, occur in Iowa on Cary (late Wisconsin) drift, in bog watersheds subjected to erosion since ice retreat 13,000 years ago. Typical closed systems at Colo and Jewell are desc...

Aman, M.G.; Sarphare, G.; Burrow, W.H., 1995: Psychotropic drugs in group homes: prevalence and relation to demographic/psychiatric variables. All 1,101 clients residing in over 120 group homes of a residential services agency were surveyed on one date for presence of psychotropic medication. In all, 27% received one or more psychotropic drugs for behavioral or emotional disorders. Disor...

Amuzu, H.; Wilson, M.D.; Boakye, D.A., 2010: Studies of Anopheles gambiae s.l (Diptera: Culicidae) exhibiting different vectorial capacities in lymphatic filariasis transmission in the Gomoa district, Ghana. Two lymphatic filariasis endemic communities Mampong and Hwida in Ghana have been regularly monitored for impact on transmission after annual mass drug administration (MDA) with albendazole and ivermectin. After six MDAs even though the ABR for Ma...

Jantunen, E.; Kuittinen, T.; Nousiainen, T., 2000: Amifostine preceding high-dose melphalan and autologous stem cell transplantation in myeloma patients A pilot study. To evaluate feasibility and potential efficacy of amifostine (AMI) in the prevention of toxicities associated with high-dose melphalan (MEL) supported by autologous stem cell transplantation (ASCT), ten myeloma patients (3 M, 7 F, median age 60 yr...