geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Treatment of acute lymphoid leukemia in children


, : Treatment of acute lymphoid leukemia in children. La Revue du Praticien 46(1): 48-54

Nowadays 95% of children with acute lymphoblastic leukemia (ALL) achieved complete remission within four to six weeks and 70% are completely cured. An important principle is that treatment should vary to prognosis and intensification of prognostic factors is of paramount importance. Leukemic patients with a good prognosis should be spared of toxic treatment. In contrast, intensive treatment should be the rule for patients with reduced probability of long term survival. In most of the protocols, induction is followed by consolidation and intensification. Duration of maintenance treatment is 18 to 24 months. Central nervous system prophylaxis associates intrathecal treatment and high dose methotrexate whereas skull irradiation must be limited to children who have high risk of meningeal relapse. Marrow relapses remain a very difficult problem. With a new induction treatment, a second remission can be achieved in 75 to 90% of patients. Bone marrow transplantation is the treatment of choice for relapses occurring on treatment. For CNS relapses skull irradiation is mandatory with a new intensive treatment in order to avoid bone marrow relapse. During treatment peculiar attention must be payed to the occurrence of bacterial infection. These infections are related to white blood cell aplasia, antibiotics must be started immediately and in some cases the use of growth factors is discussed. Immune deficiency during maintenance treatment increases the risk of viral infections. Most of the surviving children have a good quality of life without major impairment of physical, intellectual or psychological functions.

US$29.90

PMID: 8596891


Other references

Grantz, K.H.; Rane, M.S.; Salje, H.; Glass, G.E.; Schachterle, S.E.; Cummings, D.A.T., 2016: Disparities in influenza mortality and transmission related to sociodemographic factors within Chicago in the pandemic of 1918. NlmCategory="UNASSIGNED">Social factors have been shown to create differential burden of influenza across different geographic areas. We explored the relationship between potential aggregate-level social determinants and mortality dur...

Park, H-Jin.; Kim, S.Soo.; Lee, S-Yeon.; Park, N-Hyuck.; Park, J-Yeon.; Choi, Y-Jung.; Jeon, H-Jun., 2013: A practical MRI grading system for osteoarthritis of the knee: association with Kellgren-Lawrence radiographic scores. To propose a reproducible and constant MR grading system for osteoarthritis of the knee joint that provides high interobserver and intraoberver agreement and that does not require complicated calculation procedures. This retrospective study sample...

Choudhary, M.; Tamrakar, A.; Singh, A.Kumar.; Jain, M.; Jaiswal, A.; Kodgire, P., 2017: AID Biology: A pathological and clinical perspective. Activation-induced cytidine deaminase (AID), primarily expressed in activated mature B lymphocytes in germinal centers, is the key factor in adaptive immune response against foreign antigens. AID is responsible for producing high-affinity and high...

Scharner, E.S.harner, W., 1967: Impedance measurement of normal and pathologically lesioned milk. Monatshefte fur Veterinarmedizin: 5, 22 (14) 566-571

Ohlendieck K.; Ryan N.M., 1989: Immunocytochemical localization of calcium dependent atpase in rabbit fast twitch skeletal muscle. Biochemical Society Transactions 17(4): 673-674

Maxwell, G.M.; White, D.H., 1960: Fibroelastosis of the heart: clinical and haemodynamic features of eighteen cases. Medical Journal of Australia 47(2): 774-778

Levitan H.L., 1981: Failure of the defensive functions of the ego in dreams of psycho somatic patients. Four types of recurrent dreams regularly encountered in psychosomatic patients are presented. Three of the types of dreams demonstrate a total failure of the defensive functions of the ego. A 4th type demonstrates a nearly total failure. The impli...

Anonymous, 2011: Comparison of Neurosphere-like Cell Clusters Derived from Dental Follicle Precursor Cells and Retinal Muller Cells. Unrelated cells such as dental follicle precursor cells (DFPCs) and retinal M ller cells (MCs) make spheres after cultivation in serum-replacement medium (SRM). Until today, the relation and molecular processes of sphere formation from different c...

Sandler, R., 1981: Rain, rain, don't go away, Mommy wants to play. American Journal of Nursing 81(5): 1080-1080

Rauscher W., 1989: Drillability and boring behavior of hard rock tunnelling machines. Geotechnik 12(2): 67-76