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Use of gonadotrophin-releasing hormone agonists to trigger ovulation


, : Use of gonadotrophin-releasing hormone agonists to trigger ovulation. Human Fertility 5(1): G35-7; Discussion G38-9, G41-8

The introduction of gonadotrophin-releasing hormone (GnRH) agonists combined with gonadotrophins is considered to be one of the most significant advances in the development of in vitro fertilization (IVF) treatment. However, ovarian hyperstimulation syndrome (OHSS) remains a significant complication of controlled ovarian hyperstimulation. One possible strategy to reduce the risk of this complication would be the use of GnRH agonists instead of human chorionic gonadotrophin (hCG) to trigger the final stages of oocyte maturation. GnRH agonists are able to induce an endogenous surge of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and the effect may be more physiological than that of exogenous hCG. Several uncontrolled and controlled clinical studies have confirmed the efficacy of GnRH agonists for triggering ovulation, and pregnancy rates are comparable to those achieved with hCG. The incidence of OHSS appears to be decreased, but larger controlled studies are required to confirm this observation. The recent introduction of GnRH antagonists has led to renewed interest in the use of GnRH agonists to induce final oocyte maturation. An international multicentre randomized controlled trial has been completed recently comparing the efficacy of GnRH agonist with hCG for triggering ovulation in women undergoing controlled ovarian hyperstimulation using the GnRH antagonist ganirelix for pituitary suppression. The aim of the study was to determine the efficacy of the novel protocol for ovarian stimulation before IVF, in terms of pregnancy outcomes and the prevention of OHSS.

US$29.90

PMID: 11939159


Other references

Koecke, K., 1958: Primary rheographic blood pressure determination. Zeitschrift für Klinische Medizin 155(4): 345-358

Zenker, W.; Zenker, A., 1955: Activity of the jaw muscles and their electromyographical analysis. Zeitschrift für Anatomie und Entwicklungsgeschichte 119(2): 174-200

Shapiro, E.C.; Lane, M.S.; Driscoll, S.G.; Books, E.F., 1980: The supply of reduced-schedule residencies. Journal of the American Medical Women's Association 35(2): 42, 47-50

Ali, S.N.; Pleat, J.M.; Jones, A., 2004: An alcoholic solution to drain irritation. Plastic and Reconstructive Surgery 114(1): 276-276

Ajogi, I.; Desbordes, C.K., 1995: Seasonal prevalence of Cephalopina titillator myiasis in camels (Camelus dromedarius) in Sokoto State, Nigeria. Dissected heads of 528 camels slaughtered at the Sokoto city abattoir were examined for the larvae of Cephalopina titillator between March 1991 and February 1992. Three hundred sixty seven (69.9%) of them were infected. The monthly prevalence rate...

Takacs, A.M.; Barik, S.; Das, T.; Banerjee, A.K., 1992: Phosphorylation of specific serine residues within the acidic domain of the phosphoprotein of vesicular stomatitis virus regulates transcription in vitro. The phosphorylated state of the vesicular stomatitis virus phosphoprotein (P), an essential component of the virion-associated RNA polymerase complex, has been shown to be important for the transcriptional activity of the complex. Recent studies i...

Elberg, G.; He, Z.; Li, J.; Sekar, N.; Shechter, Y., 1997: Vanadate activates membranous nonreceptor protein tyrosine kinase in rat adipocytes. The insulin-like effects of vanadate are independent of the insulin receptor and insulin receptor substrate 1 (IRS-1) phosphorylation. A cytosolic protein tyrosine kinase (CytPTK), sensitive to inhibition by nanomolar concentrations of staurospori...

Lieberman, P.M., 2008: Chromatin organization and virus gene expression. Many viruses introduce DNA into the host-cell nucleus, where they must either embrace or confront chromatin factors as a support or obstacle to completion of their life cycle. Compared to the eukaryotic cell, viruses have compact and rapidly evolv...

Perona, G.; Guidi, G.C.; Piga, A.; Cellerino, R.; Milani, G.; Colautti, P.; Moschini, G.; Stievano, B.M., 1979: Neonatal erythrocyte glutathione peroxidase deficiency as a consequence of selenium imbalance during pregnancy. The red blood cell (RBC) glutathione peroxidase (GSH-Px) activity and routine haematological parameters were measured in 38 healthy north Italian full-term pregnant women and in their newborn infants. In 31 pairs the serum selenium concentration w...

Fritsche, E.; Brüning, T.; Jonkmanns, C.; Ko, Y.; Bolt, H.M.; Abel, J., 1999: Detection of cytochrome P450 1B1 Bfr I polymorphism: genotype distribution in healthy German individuals and in patients with colorectal carcinoma. Pharmacogenetics 9(3): 405-408