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Utilization of the nephrectomized mouse for determining threshold effects of MRI contrast agents

, : Utilization of the nephrectomized mouse for determining threshold effects of MRI contrast agents. Magnetic Resonance Imaging 17(4): 569-575

The tissue concentration of an extravascularly distributed MRI contrast agent required to achieve a 20% change in the MRI signal intensity (SI) of skeletal muscle was determined using radiolabeled gadoteridol administered to nephrectomized mice. This minimal change in the quantified SI was reliably detected qualitatively in the MR muscle images. MR images of muscle were acquired following each intravenous injection of six sequential doses of 0.8 micromol of 153Gd-labeled gadoteridol. A 2.0 T imaging spectrometer and a T1-weighted spin-echo pulse sequence were used to acquire the MR images. After imaging, the injected 153Gd in muscle was measured, and the 153Gd assay results were used to determine the gadoteridol concentration in muscle following each injection. The muscle concentrations of gadoteridol were then correlated to the quantified enhanced MR SI of muscle. Using the 20% factor, it was concluded that the amount of gadoteridol necessary to achieve a reliable change in the SI of muscle was 33+/-10 nmol/g-skeletal muscle.


PMID: 10231183

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Suzuki, A.; Igarashi, K.; Aisaki, K-Ichi.; Kanno, J.; Saga, Y., 2010: NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs. Nanos is one of the evolutionarily conserved proteins implicated in germ cell development. We have previously shown that NANOS2 plays an important role in both the maintenance and sexual development of germ cells. However, the molecular mechanisms...

Miller, H.K., 1950: An exploratory study of linear interpolation. Journal of Applied Psychology 34(5): 367-370

Bartlett, P.A.; Brauman, J.L.; Johnson, W.S.; Volkman, R.A., 1973: Concerning the mechanism of a nonenzymic biogenetic-like olefinic cyclization. Journal of the American Chemical Society 95(22): 7502-7504

M.B.ucher; G.F.vreau; J.M.V.uillamoz; Y.N.zoumou; A.L.gchenko, 2009: Estimating specific yield and transmissivity with magnetic resonance sounding in an unconfined sandstone aquifer Niger. The unconfined aquifer of the Continental Terminal in Niger was investigated by magnetic resonance sounding (MRS) and by 14 pumping tests in order to improve calibration of MRS outputs at field scale. The reliability of the standard relationship u...

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Farquhar, J.D., 1970: Results with the Cendehill rubella vaccine in postpartum women. Obstetrics and Gynecology 35(6): 841-843

Lipps, Jere H., 1993: Introduction to fossil prokaryotes and protists. Lipps, J H [Editor] Fossil prokaryotes and protists : 1-10

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Harding G.B.; Burton R.M.; Stroupe S.D.; Westphal U., 1974: Steroid protein interactions part 28 the iso electric point and ph stability of the progesterone binding globulin. Life Sciences 14(12): 2405-2412

Carranza, J.E.; Fisher, B.T.; Yoder, G.D.; Hahn, D.W., 2001: On-line analysis of ambient air aerosols using laser-induced breakdown spectroscopy. Laser-induced breakdown spectroscopy is developed for the detection of aerosols in ambient air, including quantitative mass concentration measurements and size/composition measurements of individual aerosol particles. Data are reported for ambient...