geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A population based, unselected, consecutive cohort of patients with acquired haemophilia A


, : A population based, unselected, consecutive cohort of patients with acquired haemophilia A. British Journal of Haematology 124(1): 86-90

Previous studies in acquired haemophilia A have reported on cohorts of patients referred to specialist centres or were retrospective surveys of specialist centre experience. This may have resulted in the literature representing a more severe group of patients than seen in routine haematological practice. We report on a consecutive, unselected cohort of all patients in south and west Wales who presented with acquired haemophilia A between 1996 and 2002. There were 18 patients, an incidence of 1.34/million/year. Compared with previously reported cohorts our patients were older, with a median age of 70 years, and less likely to have an underlying diagnosis (27%). The bleeding phenotype was less severe, with only 27% having life or limb threatening bleeds and 41% required no haemostatic treatment. One patient died of bleeding, but three died of complications related to immunosuppression. Response to immunosuppression was high compared with other series, with 88% of treated patients attaining an undetectable inhibitor and normal factor VIII level. These data suggest that previously reported cohorts may represent more severely affected patients and, whilst guidelines for treatment based on these assumptions may be valid for severely affected patients, they may not be universally applicable.

US$29.90

PMID: 14675412


Other references

Simões, J.; Potes, J.; Azevedo, J.; Almeida, J.C.; Fontes, P.; Baril, G.; Mascarenhas, R., 2004: Morphometry of ovarian structures by transrectal ultrasonography in Serrana goats. The accuracy of transrectal real-time ultrasonography (RTU) scanning technique to detect ovarian structures (follicles and corpus luteum) of Serrana goats was compared to the data obtained by observation of ovarian sequential slices. This slicing...

Kim, T.Young.; Jang, I.Hyuk.; Han, D.Yeol.; Lee, W.Gu., 2017: Quantitative image analysis of the shape and size of circular wound sites generated by vertically stamped scratches. A protocol for quantitative image analysis of wound generation is important to better understand the integrative process of wound healing and the closure mechanism. Here, we present a method for quantitative analysis of microscopic images of circu...

Rosas, A.; D.C.stro, J.M.ria Bermudez, 1999: The ATD6-5 mandibular specimen from Gran Dolina Morphological study and phylogenetic implications. Metric and shape features of the Lower Pleistocene mandibular specimen ATD605 from the level 6 of Gran Dolina site (Atapuerca, Spain) are compared with a large sample of fossil hominid mandibles. The analysis shows that ATD6-5 displays a generaliz...

Prickett, J.R.; Zimmerman, J.J., 2011: The development of oral fluid-based diagnostics and applications in veterinary medicine. The purpose of this review was to discuss the history of the development and implementation of oral fluid diagnostics for infectious diseases of humans and domestic animals. The use of oral fluid for the assessment of health and diagnosis of disea...

Anonymous, 2006: Natural products: a chance for the future of mankind. Proceedings of the International Society for the Development of Natural Products Fourth International Conference on Natural Products. May 28-31, 2006. Leysin, Switzerland. Phytochemical Analysis 17(3): 144-216

Igarashi, Y.; Nishide, S.; Ishino, Y., 1983: (Patient education) Instructing the amputated patient in positioning and wound protection. Nursing Technique 29(13): 1772-1775

Juni, S.; Straehle, M.E., 2002: Ego function assessment of nonclinical individuals. Ego Function Assessment was adapted into a self-report inventory yielding 12 operationalized function measures. 426 respondents from a stratified sample completed the inventory. In addition, 42 respondents completed the inventory twice within a 20...

Anonymous, 1945: Nutritive value of milk fat. No other fat contains such a variety of fatty acids as milk fat; it appears to exert more beneficial effects in the diet than other fats, probably through an influence on vit.-producing intestinal organisms. It is also an important carrier of fat-...

Khan, A.R.; Jaiswal, R.C., 1988: Effect of nitrogen, spacing and green fruit pickings on the seed production of okra (Abelmoschus esculentus (L.) Moench.). In 2 spring season trials with the cultivar Pusa Sawani, plants spaced at 30x15, 30x30 and 45x30 cm received N at 100 or 150 kg/ha. The pods were picked once, twice or three times with an intact control. The highest seed yield (8.33-9.02 q/ha) was...

Goward, C.R.; Stevens, G.B.; Hammond, P.M.; Scawen, M.D., 1988: Large-scale purification of the chromosomal beta-lactamase from Enterobacter cloacae P99. Homogeneous beta-lactamase (beta-lactam hydrolase, E.C. 3.5.2.6) from Enterobacter cloacae P99, an enzyme that has an important function in antibiotic resistance, was prepared using a single cation-exchange chromatographic step with CM-Sepharose f...