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ALDH2 polymorphisms and bone mineral density in an elderly Japanese population


, : ALDH2 polymorphisms and bone mineral density in an elderly Japanese population. Osteoporosis International 17(6): 908-913

Osteoporosis is a multifactorial genetic disease which greatly increases the risk of bone fracture in elderly persons. Four hundred and three recipients of a community health screening program were examined for the presence/absence of osteoporosis and 11 kinds of gene polymorphisms as a means of determining the relation between these gene polymorphisms and osteoporosis. The gene polymorphisms screened were: alcohol sensitivity-associated polymorphisms of alcohol dehydrogenase (ADH2) Arg47His, aldehyde dehydrogenase (ALDH2) Glu487Lys, smoking sensitivity-associated polymorphisms of glutathione S transferase (GST) M1, (GST)T1, NAD(P)H quinone oxidoreductase 1 (NQO1) C609T, inflammation-associated polymorphisms of interleukin-1beta (IL-1B)T-31C, tumor necrosis factor alpha (TNF-alpha) T-1031C, endothelial constitutive nitric oxide synthase (ecNOS) Glu298Asp, longevity-associated polymorphism of mitochondrial DNA (mtDNA) 5178 A/C, allergy-associated polymorphism of interleukin-4 (IL-4), and immunity-associated polymorphism of CD14. A significant association was found between the ALDH2Glu478Lys gene polymorphisms and osteoporosis. In the osteoporosis group of patients, a significant difference was noted between the Lys/Lys group and the group comprising Glu/Lys and Glu/Glu groups (namely, the genotypes including Glu alleles). In the Lys/Lys group, after age, sex, BMI, smoking history and alcohol consumption history had been adjusted for, the morbidity rate was significantly elevated [odds ratio (OR): 3.33; 95% confidence interval (95% CI): 1.28-8.71; p=0.014], and the effect was even more evident in the sub-group of women with osteoporosis (OR: 4.31; 95% CI: 1.24-14.92; p=0.021). The present results suggest that active prophylactic interventions such as dietary, exercise, and pharmacological therapies should be offered to non-carriers of the Glu allele (Lys/Lys).

US$19.90

PMID: 16520888

DOI: 10.1007/s00198-006-0077-2


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Perktold, K.; Gruber, K.; Kenner, T.; Florian, H., 1984: Calculation of pulsatile flow and particle paths in an aneurysm-model. The velocity field and the wall shear stress have been calculated numerically by the finite element method to the time-dependent Navier-Stokes equations for pulsatile flow in a model of an aneurysm. The results show a complex flow field with two e...

Babor, T.F., 1994: Overview: demography, epidemiology and psychopharmacology--making sense of the connections. This overview discusses the five papers covering demographic and prevalence issues in terms of the commonalities and differences across psychoactive substances, particularly as they pertain to the relationship between demographic factors and the p...

Nossek H.; Dobl P., 1990: Influence of zinc chloride mouth rinsings on caries induced plaque streptococci first information in vitro studies of the antimicrobial efficiency of zinc chloride on the strains of reference streptococcus mutans bht streptococcus sanguis hkop and streptococcus salivarius nctc 8618. The antimicrobial efficiency of zinc chloride solution in concentration from 0.1% to 2.0% and 0.2% chlorhexidine solution has been examined on the strains of reference in a comparative study. Three test methods were applied: the agar diffusion tes...

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Kawanishi H., 1983: Clinical and pathophysiological study on hypertrophic cardiomyopathy in special reference to the comparison of echocardiogram and electrocardiogram. Hypertrophic patterns of the left ventricular wall (LVW) in patients with hypertrophic cardiomyopathy (HCM) were classified into 4 types using 2-dimensional echocardiography and their relationship to clinical features was investigated. Subjects in...

Janion, M.; Gutkowski, W.; Sadowski, M.; Pigólak, K.; Janion-Sadowska, A.; Sielski, J., 2005: Stentgraft implantation for the treatment of coronary artery aneurysm in a patient with acute coronary syndrome. Kardiologia Polska 63(5): 558-61; Discussion 561-2

Fedarko, N.S.; Moerike, M.; Brenner, R.; Robey, P.G.; Vetter, U., 1992: Extracellular matrix formation by osteoblasts from patients with osteogenesis imperfecta. Extracellular matrix proteins synthesized by bone cells isolated from 16 patients with different forms of osteogenesis imperfecta (OI) were analyzed in vitro. Specific components of the extracellular matrix by OI and age-matched cultures were inve...

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Collin, Rachel, 1997: Ontogeny of subtle skeletal asymmetries in individual larvae of the sand dollar Dendraster excentricus. Evolution 51(3): 999-1005

Schramm, W.; Bovaird, L.; Glew, M.E.; Schramm, G.; McCracken, J.A., 1983: Corpus luteum regression induced by ultra-low pulses of prostaglandin F2 alpha. In view of the pulsatile nature of PGF2 alpha secretion from the ovine uterus at the time of luteolysis, experiments were designed to examine the effect of pulsed infusions of PGF2 alpha on luteal function and to re-examine the minimal effective l...