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Activation of the sympathetic nervous system by galanin-like peptide--a possible link between leptin and metabolism


, : Activation of the sympathetic nervous system by galanin-like peptide--a possible link between leptin and metabolism. Endocrinology 144(11): 4709-4717

The effects of leptin upon body weight (BW) cannot be explained by its anorectic actions alone. Part of the metabolic changes elicited by leptin includes sympathetic nervous system activation leading to increased energy expenditure. Galanin-like peptide (GALP), a recently described hypothalamic neuropeptide, is up-regulated by leptin and has anorectic effects in the mouse. We postulated that GALP mediates effects of leptin upon metabolism. To test this hypothesis, we administered GALP centrally to the leptin-deficient ob/ob mouse. Acutely, GALP induced a decrease in food intake and BW, both of which remained significant relative to controls for 4 d. Chronic GALP administration resulted in a sustained decrease in BW and an increase in core body temperature, despite significant recovery of food intake. In a pair-fed model, chronic GALP treatment resulted in a greater decrease in BW than that seen in controls. Furthermore, GALP treatment resulted in increased body temperature and uncoupling protein 1 mRNA and protein in brown adipose tissue compared with controls. The expression of pro-opiomelanocortin (POMC) mRNA in the arcuate nucleus was decreased after chronic GALP treatment. These observations suggest that leptin's activation of the sympathetic nervous system, and ultimately thermogenesis, may be partially mediated by GALP through a melanocortin-independent mechanism.

US$19.90

PMID: 12960003

DOI: 10.1210/en.2003-0748


Other references

Pohlentz, G.; Mokros, A.; Egge, H., 1996: Cholesterol-containing lactose derived neoglycolipids serve as acceptors for sialyltransferases from rat liver Golgi vesicles. The cholesterol-containing lactose derived neoglycolipids beta-Lactosylcholesterol, Cholesteryl-beta-lactosylpropane-1,3-diol, 3-Cholesteryl-1-beta-lactosylglycerol, 2-Cholesteryl-1-beta-lactosylglycerol, 2,3-Dicholesteryl-1-beta-lactosylglycerol,...

Huber, E.; Wiedmann, M.; Donie, F., 1999: Photo-activatable biotin derivatives and their use to reduce interference in immunoassays. Official Gazette of the United States Patent & Trademark Office Patents 1226(2), Sep 14

Jivănescu, C.Bunea.; Scurtu, R.; Funariu, G.; Verhaeghe, P.; Motocu, R.; Grecea, D.; Bumbu, C.; Gomboşiu, C.; Ciuce, C., 2007: Conservative management in blunt splenic trauma. We reviewed for analysis the charts of two groups of adults patients with blunt splenic injuries issued from two University Hospital Centers; the group 1 (G1) of 22 patients and the group 2 (G2) of 20 patients. The results of actually therapeutic...

Ng, E.Y-K.; Sudharsan, N.M., 2004: Computer simulation in conjunction with medical thermography as an adjunct tool for early detection of breast cancer. Mathematical modelling and analysis is now accepted in the engineering design on par with experimental approaches. Computer simulations enable one to perform several 'what-if' analyses cost effectively. High speed computers and low cost...

Larson, M.; Hermansson, K.; Wolgast, M., 1983: Hydraulic permeability of the peritubular and glomerular capillary membranes in the rat kidney. The hydraulic conductivity of the peritubular capillary membrane was calculated from 1) single nephron fluid reabsorption and 2) net driving force, i.e. from hydrostatic and colloid osmotic pressures in renal interstitium and peritubular capillary...

Mouratidis, B.; Lomas, F.; Hurley, B., 1995: Anastomotic leak of pancreatic transplant demonstrated by radionuclide cystography. Clinical Nuclear Medicine 20(8): 742-743

Waring, D.T.; Harrison, J.E., 2007: Reply letters following orthodontic consultations: an audit of Merseyside general dental practitioners' satisfaction. To assess the opinions of general dental practitioners (GDPs) working within the National Health Ser vice (NHS) in Merseyside regarding the length, format and appropriateness of consultant orthodontists' letters sent in reply to referral lett...

Anonymous, 1985: Proceedings of the X International Symposium on Intestinal Microecology, Minneapolis, Minnesota, October 2-3, 1985. The 8 papers on intestinal protozoa are cited individually and can be located by reference to 'Conferences, International Symposium on Intestinal Microecology, Minneapolis' in the subject index.

Merimsky, O.; Inbar, M., 1999: Alcohol intake-associated skin and mucosal cancer. Clinics in Dermatology 17(4): 447-455

Zhou Rongjun; Wen Xueze; Chai Changxing; M.S.enghao, 1997: Recent earthquakes and assessment of seismic tendency on the Ganzi-Yushu fault zone. We have studied the magnitude, epicentre of recent earthquakes, and spatial distribution of ground seismic ruptures on the Ganzi-Yushu fault. We have estimated the tendency of major earthquakes for each segment of the Ganzi-Yushu fault zone in the...