+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Allergic conjunctivitis: the forgotten disease

, : Allergic conjunctivitis: the forgotten disease. Chemical Immunology and Allergy 91: 110-120

The eye is largely exposed to foreign substances, and ocular tissues have a complete array of immune cells to interact with offending antigens. In particular, the external eye represents an ideal site for immediate hypersensitivity reactions because of the high number of mast cells in the eyelids and bulbar conjunctiva, as well as for the potential local synthesis of IgE. In fact, the involvement of the eye was part of the original description of hay fever by Charles Blackley in 1873. In a large epidemiological survey of allergic patients we reported since 1987, 40% had symptoms possibly related to allergic conjunctival disease. However, the participation of the conjunctiva to the multiorgan picture of allergy is largely underestimated. Allergic eye diseases have long been referred to the classical Type I hypersensitivity mechanism according to Coombs and Gell. Recently, however, the tremendous progress in understanding allergic mechanisms and inflammation has brought new insights into the pathophysiology of several allergic diseases, including those of the eye. Accordingly, several systematic descriptions of allergic eye diseases should be revisited. In particular, the classification of the various forms of a 'red eye' of allergic origin appears inadequate to answer the progress achieved in their multifactorial pathogenesis.


PMID: 16354953

DOI: 10.1159/000090247

Other references

Galankin, V.N., 1971: Changes in the myofibril system of the heart in congenital heart defects in neonates and infants. Arkhiv Patologii 33(1): 43-47

Tamimi, H.K.; Bolen, J.W., 1984: Enchondromatosis (Ollier's disease) and ovarian juvenile granulosa cell tumor. An ovarian juvenile granulosa cell tumor in a 15-year-old white girl is reported. The patient had enchondromatosis (Ollier's disease). amd a review of the literature revealed two previous reports linking enchondromatosis with ovarian sex-cord...

Uprichard, A.C.; Chi, L.; Lucchesi, B.R., 1993: Functional consequence of big endothelin conversion: demonstration with isolated neutrophils but not in a postinfarction model. The role of neutrophils in the conversion of big endothelin (Big-ET) to endothelin-1 (ET-1) was assessed in two models. In rabbit isolated hearts, ET-1 demonstrated significant increases in coronary perfusion pressure (PP) at doses greater than 10...

Cubilla, A.L.; Lloveras, Bén.; Alejo, Mía.; Clavero, O.; Chaux, A.; Kasamatsu, E.; Velazquez, E.F.; Lezcano, C.; Monfulleda, Núria.; Tous, S.; Alemany, L.; Klaustermeier, J.; Muñoz, N.; Quint, W.; de Sanjose, S.; Bosch, F.Xavier., 2010: The basaloid cell is the best tissue marker for human papillomavirus in invasive penile squamous cell carcinoma: a study of 202 cases from Paraguay. Human papillomavirus (HPV) has been reported in 12-82% of penile squamous cell carcinomas (SCC). There is an association of the virus with basaloid and warty carcinomas but the reported prevalence is variable. The causes of these variations are no...

Bacigalupo N.M., 1968: Revision of the species of genus richardia d rubiaceae d in the argentine flora new records. Darwiniana (San Isidro) 14(4): 639-653

Ogino, T.; Moralejo, D.H.; Kose, H.; Yamada, T.; Matsumoto, K., 2004: Serum leptin concentration is linked to chromosomes 2 and 6 in the OLETF rat, an animal model of type 2 diabetes with mild obesity. Leptin is produced by adipose tissue and acts as a feedback signal to the hypothalamus controlling energy homeostasis, by reducing food consumption and increasing energy expenditure. Because serum leptin levels are highly correlated with body fat...

Gannier, Alexandre., 1995: Notes on cetacean censusing methods of current usage in the Mediterranean Note sur les methodes de recensement de cetaces utilisees a lheure actuelle en Mediterranee. Cahiers Options Mediterraneennes, 10: 81-84

Kauppinen, R.A., 1993: 1H nuclear magnetic resonance spectroscopy identifies neural cell types: a promising step for neuroimaging?. Trends in Neurosciences 16(10): 384-386

Anonymous, 1975: Proceedings of the symposium Plant Nutrition and Horticultural Products Quality held at University of Guelph, August 14, 1974. Hortsci 10 (1) 39-58

Bellamine, J.; Greppin, H., 1997: Involvement of calcium in the in vitro sensitivity change of the plasma membrane H+ ATPase to indole-3-acetic acid. The proton pumping activity of phase-partitioning purified plasma membrane fraction from spinach leaves was tested in vitro in the presence of exogenous indole-3-acetic acid. The sensitivity of the H+ pumping activity of the auxin was changed afte...