+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Antiretroviral therapy for HIV-infected patients with schizophrenia. Coordinated multidisciplinary management (7 cases)

, : Antiretroviral therapy for HIV-infected patients with schizophrenia. Coordinated multidisciplinary management (7 cases). Presse Medicale 34(6): 431-437

Schizophrenia might appear to be an obstacle to the initiation of and especially compliance with antiretroviral therapy for HIV-infected patients. The aims of this study were to describe the clinical, immunologic and virologic course after initiation of antiretroviral therapy in 7 HIV patients with schizophrenia (according to DSM-IV-R criteria), and to analyse the possibilities of an adequate antiretroviral therapy for those patients. Multidisciplinary management by specialists in infectious diseases, addiction-related disorders, treatment adherence and compliance, and psychiatrists, as well as social workers, home care agencies, and patient advocacy and assistance groups, was organized with coordinated medical-psychiatric follow-up at least once a month. The patients, 6 men and 1 woman, were aged from 26 to 48 years; schizophrenia had been diagnosed in 5 patients 6 months to 20 years before the HIV infection was discovered; diagnoses of both diseases were essentially simultaneous for the other 2. All patients took long-term neuroleptics for their schizophrenia. Two were active drug addicts who received drug substitution treatment. Before antiretroviral treatment began, 6 patients had advanced infection: stage C with peak CD4 cell counts ranging from 6 to 70/mm3; they began treatment with protease inhibitors between May 1996 and August 1997. The seventh patient was first seen during primary HIV infection in July 1998, and treatment began then. Response to antiretroviral treatment with protease inhibitors was slow for all patients, but viral load became undetectable for 6 of the 7, after 5 months to 4 years; 3 had opportunistic infections. Follow-up ended in January 2002: 5 patients still had undetectable viral loads,, with CD4 cell counts ranging from 45 to 1 000/mm3. One patient died from mixed terminal cirrhosis (alcohol abuse and hepatitis C); the viral load in another was only partially controlled (10 000 copies/ml), because of poor treatment adherence. Individuals with schizophrenia can respond well to antiretroviral treatment, although response may appear slow; they can adhere to complex treatment regimens as long as they receive well coordinated and sustained multidisciplinary support.


PMID: 15902873

Other references

Sakai, T.; Geffner, E.S.; Sandow, A., 1971: Caffeine contracture in muscle with disrupted transverse tubules. American Journal of Physiology 220(3): 712-717

Manios, Y., 2012: The 'ToyBox-study' obesity prevention programme in early childhood: an introduction. Obesity Reviews 13 Suppl 1: 1-2

Ruiz, J.; Castilla, N.R.mero, L., 2000: Nitrogen metabolism in pepper plants applied with different bioregulators. Certain bioregulators were studied in relation to nitrogen metabolism of pepper plants (Capsicum annuum L. cv. Lamuyo). Plants were grown under controlled conditions and submitted to regular fertilization with macro-and micronutrients. Treatments...

Orendácová, J.; Chavko, M.; Fercáková, A.; Kluchová, D.; Bona, M.; Marsala, J., 1985: The fine structure of granular endoplasmic reticulum in neurons and 14C-leucine incorporation into proteins in spinal ganglia of dog after ischemia. Neuropatologia Polska 23(4): 465-474

Arora, R.C.; Hirsch, G.M.; Hirsch, K.; Armour, J.A., 2001: Transmyocardial laser revascularization remodels the intrinsic cardiac nervous system in a chronic setting. Background: Prospective trials have demonstrated that transmyocardial laser revascularization (TMLR) imparts symptomatic relief to patients with refractory angina. Because peak clinical effectiveness of TMLR is usually delayed by several months, i...

Pavicin, I.Savić.; Ivosević-Magdalenić, N.; Badel, T.; Basić, K.; Keros, J., 2013: Analysis of dental supportive structures in orthodontic therapy. The purpose was to define the impact of orthodontic appliances on the density of the underlying dental bone tissue. Radiographic images of teeth were made in 27 study subjects before and twelve months after fixed orthodontic appliances were carrie...

Rosenthaler, L., 1953: The bromination of acetanilid. Pharmaceutica Acta Helvetiae 28(10): 310-311

Picardi, N.; Grassetti, U.; Forte, A.; Pasta, V.; Monti, M.; D'Andrea, G.; Agosta, F.; Menis, C.; Rosati, R.; Vietri, F., 1981: Experimental method for research on the zero hemodynamic level in the major circulation for the experimental study of venous pressures. Annali Italiani di Chirurgia 53(3): 321-328

Lomonaco, F., 1960: On the nephrotrophic action of some testosterone 19-norderivativesr. The nephrotrophic and nephrotropic actions of 17 [alpha]-methyl-nortestosterone, 17 [alpha]-ethinyl-5-estrenolone and testosterone propionate have been studied on castrated rats. The action of 17 [alpha]-methyl-19-nortestosterone was undoubtedly g...

Mizutani, T., 2003: Postgraduate education of neurology (PGEN) in Japan. PGEN in USA consists of a 3-year well-organized program. This includes 18 months' in-patient service, and 12 months' rotation to various electives, also providing various conferences and lectures. Residents are salaried, so that they are...