geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus


, : Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus. Arthritis Research & Therapy 9(2): R23-R23

Although co-trimoxazole (trimethoprim-sulphamethoxazole) is an effective drug for prophylaxis against and treatment of Pneumocystis pneumonia, patients often experience adverse events with this combination, even at prophylactic doses. With the aim being to achieve individual optimization of co-trimoxazole therapy in patients with systemic lupus erythematosus (SLE), we investigated genetic polymorphisms in the NAT2 gene (which encodes the metabolizing enzyme of sulphamethoxazole). Of 166 patients with SLE, 54 patients who were hospitalized and who received prophylactic doses of co-trimoxazole were included in the cohort study. Adverse events occurred in 18 patients; only two experienced severe adverse events that lead to discontinuation of the drug. These two patients and three additional ones with severe adverse events (from other institutions) were added to form a cohort sample and were analyzed in a case-control study. Genotype was determined using TaqMan methods, and haplotype was inferred using the maximum-likelihood method. In the cohort study, adverse events occurred more frequently in those without the NAT2*4 haplotype (5/7 [71.4%]) than in those with at least one NAT2*4 haplotype (13/47 [27.7%]; P = 0.034; relative risk = 2.58, 95% confidence interval = 1.34-4.99). In the case-control study the proportion of patients without NAT2*4 was significantly higher among those with severe adverse events (3/5 [60%]) than those without severe adverse events (6/52 [11.5%]; P = 0.024; odds ratio = 11.5, 95% confidence interval = 1.59-73.39). We conclude that lack of NAT2*4 haplotype is associated with adverse events with co-trimoxazole in Japanese patients with SLE.

US$19.90

PMID: 17335581

DOI: 10.1186/ar2134


Other references

Qian, X.; Liu, Y.; Xiao, B.; Gao, L.; Li, S.; Dang, L.; Si, C.; Zhao, L., 2015: The visual mismatch negativity (vMMN): toward the optimal paradigm. In the present article, we tested an optimal vMMN paradigm allowing one to obtain vMMNs for several visual attributes in a short time. vMMN responses to changes in color, duration, orientation, shape, and size were compared between the traditional...

Ryder, T., 1996: Environmentally sustainable tourism: responsible interaction with the natural environment. This paper aims to explore the rationale and future prospects for tourism as a means of fostering in the consumer society more responsible attitudes towards the natural environment. It considers the need, both existential and ecological, for consu...

Parra, E.Roger.; Kairalla, R.Adib.; de Carvalho, C.Roberto.Ribeiro.; Capelozzi, V.Luiza., 2007: Abnormal deposition of collagen/elastic vascular fibres and prognostic significance in idiopathic interstitial pneumonias. Background: Vascular remodelling has recently been shown to be a promising pathogenetic indicator in idiopathic interstitial pneumonias (IIPs).Aim: To validate the importance of the collagen/elastic system in vascular remodelling and to study the...

Raushenbakh, I.; Korochkina, L.; Korochkin, L., 1976: Esterase system and endocrine system of Drosophila virilis under selection at elevated temperatures. Soviet genetics: (Transl 1977), 12 (1) 60-68

Wu-Baer, F.; Lane, W.S.; Gaynor, R.B., 1996: Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. A double-stranded RNA structure transcribed from the HIV-1 long terminal repeat known as TAR is critical for increasing gene expression in response to the transactivator protein Tat. Two cellular factors, RNA polymerase II and TRP-185, bind specif...

Y.ShouRong, 1995: Studies on the powdery mildews in Yuntaishan, Jiangsu Province of China. III. A new record species of the genus Erysiphe in China. The occurrence of E. actinostemmatis on Actinostemma lobatum is noted.

Zanotti, C.; Martinelli, N.; Lelli, D.; Amadori, M., 2016: Correlates of Protection Following Vaccination with Inactivated Porcine Circovirus 2 Vaccines. Porcine circovirus type 2 (PCV2) is associated with a number of diseases and syndromes, collectively referred to as porcine circovirus-associated disease. The main objective of this study was to define some in vitro correlates of protection after...

Umanets', N.O.; Hulyayev, B.I., 1998: Photosynthesis intensity, growth processes and grain productivity of maize hybrids under various conditions of moisture supply. The peculiarities in the response of corn hybrids Pioneer 3978 and Saturn on soil drought at the 12th leaf and tasseling stages have been studied in vegetative experiments. It has been found that the drought at the stage of tasseling more signific...

Zeng, V.; Ewen-Campen, B.; Horch, H.W.; Roth, S.; Mito, T.; Extavour, C.G., 2013: Developmental gene discovery in a hemimetabolous insect: de novo assembly and annotation of a transcriptome for the cricket Gryllus bimaculatus. Most genomic resources available for insects represent the Holometabola, which are insects that undergo complete metamorphosis like beetles and flies. In contrast, the Hemimetabola (direct developing insects), representing the basal branches of th...

Haasis, R.; Larbig, D.; Burck, H.C., 1975: Comparative studies between serum glycoside concentration and systolic time intervals in healthy subjects following administration of beta-methyldigoxin. Verhandlungen der Deutschen Gesellschaft für Innere Medizin 81: 1664-1666