+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary study

, : Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary study. Psychiatry Research 130(3): 269-281

In untreated smokers, exposure to cigarette-related cues increases both the intensity of cigarette craving and relative glucose metabolism of the perigenual/ventral anterior cingulate cortex (ACC). Given that treatment with bupropion HCl reduces overall cigarette craving levels in nicotine dependent subjects, we performed a preliminary study of smokers to determine if bupropion HCl treatment attenuates cue-induced cigarette craving and associated brain metabolic activation. Thirty-seven, otherwise healthy smokers (20 untreated and 17 who had received open-label treatment with bupropion HCl) underwent two (18)F-fluorodeoxyglucose positron emission tomography scanning sessions in randomized order--one when presented with neutral cues and the other when presented with cigarette-related cues. Bupropion-treated smokers had smaller cigarette cue-induced increases in craving scores on the Urge to Smoke (UTS) Scale and less activation of perigenual/ventral ACC metabolism from the neutral to the cigarette cue scan than untreated smokers. Thus, in addition to its known effects on spontaneous cigarette craving and withdrawal symptoms, bupropion HCl diminishes cue-induced cigarette craving and appears to attenuate cigarette cue-induced ACC activation. These results are consistent with the known effects of bupropion HCl, including its enhancement of catecholaminergic neurotransmission.


PMID: 15135160

DOI: 10.1016/j.pscychresns.2003.12.006

Other references

Pack, A.R., 1991: The transition of the Journal during 1981-91. Journal of the New Zealand Society of Periodontology: 24-26

Pérez-Lozano, P.; García-Montoya, E.; Orriols, A.; Miñarro, M.; Ticó, J.R.; Suñé-Negre, J.M., 2005: A new validated method for the simultaneous determination of benzocaine, propylparaben and benzyl alcohol in a bioadhesive gel by HPLC. A new HPLC-RP method has been developed and validated for the simultaneous determination of benzocame, two preservatives (propylparaben (nipasol) and benzyl alcohol) and degradation products of benzocame in a semisolid pharmaceutical dosage form (...

Horvath, E., 1973: Evaluation of the economics of management of (Czechoslovak) unified agricultural co-operatives and state farms. The economics of management of 323 unified agricultural co-operatives and state farms in 11 districts of Czechoslovakia was investigated, and expressed by indices of productivity of labour of the specialist and economic workers and by indices of c...

Gittoes, O.M.J.; Gittoes, N.J.L., 2017: Breathlessness and neck swelling after a rugby game. Bmj 356: J311-J311

Szekielda K H., 1969: The determination of particulate carbon in sea water and its application in the gulf of lions. Journal du Conseil Conseil International pour l'Exploration de la Mer 32(3): 318-343

Ereshefsky, B.J.; Al-Hasan, M.N.; Gokun, Y.; Martin, C.A., 2016: Comparison of ß-lactam plus aminoglycoside versus ß-lactam plus fluoroquinolone empirical therapy in serious nosocomial infections due to Gram-negative bacilli. NlmCategory="UNASSIGNED">We sought to compare clinical cure on day 7 and a 28-day all-cause mortality in patients who received an anti-pseudomonal ß-lactam with a fluoroquinolone or an aminoglycoside for treatment of nosocomial bacte...

Andersen, D.Caroline.; Jensen, C.Harken.; Baun, C.; Hvidsten, S.; Zebrowski, D.C.; Engel, F.Benedikt.; Sheikh, Søren.Paludan., 2016: Persistent scarring and dilated cardiomyopathy suggest incomplete regeneration of the apex resected neonatal mouse myocardium--A 180 days follow up study. Heart damage in mammals is generally considered to result in scar formation, whereas zebrafish completely regenerate their hearts following an intermediate and reversible state of fibrosis after apex resection (AR). Recently, using the AR procedur...

Dutt, A.K.; Balasegaram, M.; Bin Din, O., 1969: Alveolar soft-part sarcoma with invasion of bone. A case report. Journal of Bone and Joint Surgery. American Volume 51(4): 765-768

Young, E.; Cesena, T.; Strzyzewski, M.; Meiri, K.; Perrone Bizzozero, N.I., 1999: Fear conditioning alters hippocampal protein kinase C and GAP-43. Society for Neuroscience Abstracts 25(1-2): 879

Mounier-Kuhn, P.; Gaillard, J.; Haguenauer, J.P., 1965: Intra-arterial chemotherapy in cervico-facial cancerology. Journal de Medecine de Lyon 46(87): 1849-1862