geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Bioassay of chloramben for possible carcinogenicity


, : Bioassay of chloramben for possible carcinogenicity. National Cancer Institute Carcinogenesis Technical Report Series 25: 1-90

A bioassay of technical-grade chloramben for possible carcinogenicity was conducted by administering the test material in feed to Osborne-Mendel rats and B6C3F1 mice. Groups of 50 rats and 50 mice of both sexes were administered chloramben at one of two doses, either 10,000 or 20,000 ppm. The rats were treated for 80 weeks, then observed for 32 or 33 weeks; the mice were treated for 80 weeks, then observed for 11 or 12 weeks. Matched controls consisted of groups of 10 untreated rats and 10 untreated mice of each sex; pooled controls, used for statistical evaluation, consisted of these matched controls combined with 75 untreated male and 75 untreated female rats or 70 untreated male and 70 untreated female mice from similarly performed bioassays of six other test chemicals. Surviving rats were killed at 112 or 113 weeks; surviving mice were killed at 91 or 92 weeks. Body weights and mortality of the treated animals were not markedly affected by chloramben under the conditions of the bioassay. The various clinical signs observed were common to both treated and control groups. In male rats, hemangiomas occurred at a significantly higher incidence in the low-dose animals than in the pooled controls (controls 0/73, low-dose 5/48, P=0.009). This lesion was not considered to be related to the administration of chloramben, since the tumor did not occur at a significantly higher incidence in the high-dose group than in the pooled-control group, and the incidences did not show a significant dose-related trend. In both male and female mice, the incidences of hepatocellular carcinoma showed significant dose-related trends using pooled controls (for females: controls 9/69, low dose 16/48, high-dose 14/48, P=0.029; for females controls 2/67, low-dose 7/48, high-dose 10/50, P=0.004). Direct comparisons showed significantly higher incidences of the tumor in the low-dose males (P=0.008) and in the high-dose females (P=0.003) than in the pooled controls. Probability levels of P=0.028 in high-dose males and P=0.027 in low-dose females were attained. In male mice, however, the incidence of hepatocellular carcinoma was considered to be only marginally associated with the administration of chloramben because of the variations in the spontaneous incidence of this lesion in male mice encountered at this laboratory. In conclusion, under the conditions of this bioassay, there were no tumors in Osborne-Mendel rats that were significantly related to administration of the chemical. In B6C3F1 female mice, chloramben was carcinogenic, producing hepatocellular carcinomas in treated animals.

US$29.90

PMID: 12844183


Other references

Venkateswaran, A., 1975: Adhesion of wood. A survey with particular reference to developments in the last five years. Principal headings: testing of adhesives and adhesion; mechanisms of adhesion; bonding processes and applications; factors affecting adhesion: effects of pressure or stress...

Geekie, D.A., 1973: Professional accountability and evaluation. Canadian Medical Association Journal 109(5): 346-346

Borges, M.da.Silva.; Santos, Mília.Borges.Couto.; Pinheiro, T.Gomes., 2015: Social representations about religion and spirituality. to identify the social representations about the concepts of spirituality and religion of of health teachers. exploratory and descriptive study, based on a qualitative approach. 25 subjects participated in it. The following instruments were used t...

Pavlovic, A.; Glavina Durdov, M.; Lozic, D.; Skare Librenjak, L.; Alfirevic, D., 2016: Primary ovarian lymphoma and benign Brenner tumor. Taiwanese Journal of Obstetrics & Gynecology 55(1): 138-139

Honig P.K.; Zamani K.; Woosley R.L.; Conner D.P.; Cantilena L.R.Jr, 1992: Erythromycin changes terfenadine pharmacokinetics and electrocardiographic pharmacodynamics. Clinical Pharmacology & Therapeutics 51(2): 156

Pitlick John, 1994: Relation between peak flows, precipitation, and physiography for five mountainous regions in the Western USA. Flood frequency curves are presented for five regions in the western USA characterized by diverse climate but similar physiography. The regional curves are obtained via an index flood method based on probability-weighted moments of the generalized...

Schimpff, S.C.; Landesman, S.; Hahn, D.M.; Standiford, H.C.; Fortner, C.L.; Young, V.M.; Wiernik, P.H., 1976: Ticarcillin in combination with cephalothin or gentamicin as empiric antibiotic therapy in granulocytopenic cancer patients. Ticarcillin was used in combination with either cephalothin or gentamicin as initial empiric antibiotic therapy for 127 patient trials of suspected infection in granulocytopenic cancer patients. Bacteremia was present in 20%, nonbacteremic microbi...

Blake, N.M.; Kirk, R.L.; McDermid, E.M.; Omoto, K.; Ahuja, Y.R., 1971: The distribution of serum protein and enzyme group systems among North Indians. Human Heredity 21(5): 440-457

Fornari, F.; Farré, R.; van Malenstein, H.; Blondeau, K.; Callegari-Jacques, S.M.; Barros, S.G.S., 2008: Nutcracker oesophagus: association with chest pain and dysphagia controlling for gastro-oesophageal reflux. The association between nutcracker oesophagus, gastro-oesophageal reflux and their symptoms is controversial. To evaluate the association of nutcracker oesophagus with chest pain and dysphagia controlling for gastro-oesophageal reflux. From a data...

Hiday, V.A.; Ray, B., 2010: Arrests two years after exiting a well-established mental health court. Relatively few studies have evaluated whether mental health courts reduce criminal recidivism. This study evaluated an established court and followed for two years defendants who exited the program in the court's fifth year of operation. Cour...