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Can genital-tract human papillomavirus infection and cervical cancer be prevented with a vaccine?


, : Can genital-tract human papillomavirus infection and cervical cancer be prevented with a vaccine?. Expert Reviews in Molecular Medicine 6(9): 1-21

Human papillomavirus (HPV) infection is the cause of squamous cell carcinoma of the uterine cervix. This causative relationship has provided the rationale and incentive for development of a prophylactic vaccine. Such a vaccine, if found to be effective, could reduce the need for cervical cancer screening and have a profound effect on the incidence of cervical and other anogenital cancers. This review begins by examining the basic biological and epidemiological principles relevant to the development of HPV preventative vaccines. It then summarises studies examining the use of vaccines to prevent HPV infection in animals and humans, and, finally, discusses some of the unanswered issues surrounding vaccine development against HPV infection and cervical cancer.

US$19.90

PMID: 15096282

DOI: 10.1017/S1462399404007653


Other references

Fukushima, T., 1968: Working conditions of the public health nurse. Japanese Journal for Public Health Nurse 24(10): 51-51

Richardson, C.D.; Scheid, A.; Choppin, P.W., 1980: Specific inhibition of paramyxovirus and myxovirus replication by oligopeptides with amino acid sequences similar to those at the N-termini of the F1 or HA2 viral polypeptides. Virology 105(1): 205-222

Wang, S-jie.; Guo, X.; Zuo, H.; Zhang, Y-gang.; Xu, P.; Ping, Z-guang.; Zhang, Z-tie.; Geng, D., 2005: Chondrocyte apoptosis and the expression of Bcl-2, Bax, Fas and iNos in articular cartilage in Kashin-Beck disease. To investigate the characteristics of chondrocyte apoptosis and distribution of Bcl-2, Bax, Fas and iNos expressions in articular cartilage in Kashin-Beck disease (KBD). Samples of articular cartilage were collected from 15 healthy children and 15...

Asano, T.; McWatters, A.; An, T.; Matsushima, K.; Kleinerman, E.S., 1994: Liposomal muramyl tripeptide up-regulates interleukin-1 alpha, interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 gene expression in human monocytes. Liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (L-MTP-PE) is a new biologic agent presently in clinical trials for metastatic osteosarcoma and melanoma. The mechanism of L-MTP-PE antitumor activity is linked to its activation of...

Sabate, R.; Rousseau, F.; Schymkowitz, J.; Ventura, S., 2015: What makes a protein sequence a prion?. Typical amyloid diseases such as Alzheimer's and Parkinson's were thought to exclusively result from de novo aggregation, but recently it was shown that amyloids formed in one cell can cross-seed aggregation in other cells, following a p...

Schultz, O.E.; Mohrmann, H.L., 1965: A contribution to the analysis of the contents of garlic--Allium sativum L. I. Thin-layer chromatography of garlic oil. Die Pharmazie 20(6): 379-381

Fleischmajer, R.; Olsen, BR.; Kuhn, K., 1985: Biology, chemistry, and pathology of collagen. Annals of the New York Academy of Sciences 460: 1-537

Anonymous, 2015: CMS issues infection control survey. Hospital Case Management 23(2): 21-23

Roberts, M.J.; Vogfjord, K.S.; Slunga, R., 2008: Seismic observations of glacial flooding from the ice cover of Katla Volcano, Iceland. Geophysical Research Abstracts 10

Yang, T.Hoon.; Wittmann, C.; Heinzle, E., 2003: Dynamic calibration and dissolved gas analysis using membrane inlet mass spectrometry for the quantification of cell respiration. A membrane inlet mass spectrometer connected to a miniaturized reactor was applied for dynamic dissolved gas analysis. Cell samples were taken from 7 mL shake flask cultures of Corynebacterium glutamicum ATCC 13032, and transferred to the 12 mL mi...