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Caspase and calpain function in cell death: bridging the gap between apoptosis and necrosis


, : Caspase and calpain function in cell death: bridging the gap between apoptosis and necrosis. Annals of Clinical Biochemistry 42(Pt 6): 415-431

Calpain and caspase are families of cysteine proteases that have important roles in the initiation, regulation and execution of cell death. The function of both groups of proteases in the progression of apoptotic and necrotic pathways is presented here in the context of a concise overview of regulated cell death. Many of the morphological differences between apoptotic and necrotic processes are thought to be as a consequence of the action of cysteine proteases. Recent studies suggest that caspase and calpain cascades are tightly interrelated and an appreciation of how these proteases cross-talk should enable a greater understanding of how the boundaries between apoptotic and necrotic cell death have become blurred. Furthermore, an assessment of the contribution that caspase and calpain make to human physiology and pathology is provided, with a description of how these proteases can be detected and quantified. Lastly, an evaluation is made of how caspase and calpain activation might be exploited diagnostically.

US$19.90

PMID: 16259792

DOI: 10.1258/000456305774538238


Other references

Yarborough, D.E., 1997: Production trends in the wild blueberry industry in North America. Wild blueberries (Vaccinium angustifolium) are produced commercially in the state of Maine, USA, and in Canada. The crop has tripled in the last 15 years and most of the improvements have been due to better field management, in the areas of weed c...

Olin, J.W.; Graor, R.A.; Young, J.R., 1989: Thrombolytic therapy for renal artery occlusions: a preliminary report. Percutaneous transluminal angioplasty and renal artery revascularization have been successful in controlling blood pressure and preserving renal function in patients with atherosclerotic renal artery stenosis. In addition, thrombolysis appears pro...

Kleinschmidt, A.; Lee, B.B.; Requardt, M.; Frahm, J., 1996: Functional mapping of color processing by magnetic resonance imaging of responses to selective P- and M-pathway stimulation. Magnetic resonance imaging sensitized to activity-related changes in cerebral blood oxygenation was performed to map responses to selective stimulation of the parvo- and magnocellular visual pathways in calcarine and adjacent ventral occipital cor...

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Chen, M.S.; Schirch, L.V., 1973: Serine transhydroxymethylase. Studies on the role of tetrahydrofolate. Journal of Biological Chemistry 248(23): 7979-7984

Savarie, P.; Tigner, J.; Elias, D.; Hayes, D., 1980: Development of a simple two-ingredient pyrotechnic fumigant. Proceedings Vertebrate Pest Conference: th) 215-221

Chandiwana, S.K., 1984: Malaria and bilharzia, and other water-borne diseases, and their control in Zimbabwe. Schistosoma and Plasmodium infections in Zimbabwe are reviewed. Recommendations for the control of water-related and vector borne diseases are presented with particular reference to Schistosoma and Plasmodium control in irrigation schemes. Methods...

Messerschmidt, O., 1954: Cystoma of nephrogenic tissue. Zeitschrift für Urologie 47(10): 647-655

Armstrong, B.; Kinn, S.; Scoular, A.; Wilson, P., 2003: Shared care in the management of genital Chlamydia trachomatis infection in primary care. Objectives: To investigate the impact of a health adviser in genitourinary medicine as a training and support resource on the management of Chlamydia trachomatis in a large inner city health centre. Methods: A large, inner city health centre was s...

El-Hennawy, Hisham K., 1997: Index aranearum. Part 5. (Hypochilidae, Austrochilidae, Gradungulidae, Filistatidae, Sicariidae, Scytodidae, Drymusidae, Leptonetidae). Serket. September; 53: 117-146