geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Chordoid meningioma, an uncommon variant of meningioma: a clinicopathologic study of 12 cases


, : Chordoid meningioma, an uncommon variant of meningioma: a clinicopathologic study of 12 cases. Journal of Neuro-Oncology 78(3): 263-269

The study has been undertaken to document the clinicopathological features of 12 cases of chordoid meningioma, operated at All India Institute of Medical Sciences during 1996 to June 2005. Clinical information was retrieved from the records of our Neurosurgery Department. The cases were stained with H&E, Periodic Acid Schiff (PAS) with and without diastase, mucicarmine, giemsa, toluidine blue, alcian blue, reticulin and Masson trichrome. Immunohistochemistry for pancytokeratin, epithelial membrane antigen, vimentin, glial fibrillary acidic protein, MIB-1, Leucocyte common antigen (LCA), CD-3 and CD-20 was done in all cases. The age ranged from 12-67 years (mean 34.2 years) and three of them occurred in < 18 years. Male to female ratio was 1:1.4. The duration of symptoms varied from 3.5 months to 5 years (mean 14.1 months). No systemic symptoms were noted. The location of tumor in eight cases was in the supratentorial and rest four in the infratentorial compartments. Interestingly, two cases were in intraventricular location, one in the lateral ventricle and other in the fourth ventricle. Microscopic examination showed lobulation with chordoid elements constituting > 95% of the entire tumor area in 11 of the total 12 cases. In one case, chordoid pattern constituted about 30% of the total tumor area; the rest was predominant meningothelial (60%). Mild to severe lymphoplasmacytic cell infiltrate was present in all cases. The histochemical stains showed the pattern of acidic mucin and interestingly revealed the presence of mast cells both in connective tissue stroma and epithelial cell islands. The inflammatory infiltrate was B-cell predominant. MIB-1 labeling index was low (< 2%) in all cases except two, which showed LI of 6% and 8%. Strong diffuse immunoreactivity for vimentin and focal positivity for epithelial membrane antigen was noted in all cases. Chordoid meningiomas are predominantly tumors of young adults with predilection for supratentorial location. Intraventricular location, absence of systemic manifestations despite the presence of abundant B-lymphocytes, presence of mast cells and low MIB-1 LI are some of the interesting findings in the present series, which need documentation. Hence, larger number of cases with adequate follow-up data need to be studied further to establish the clinical significance of this variant.

US$19.90

PMID: 16628477

DOI: 10.1007/s11060-005-9092-y


Other references

Riding, J.E.; Robinson, J.S., 1961: The safety of neostigmine. Anaesthesia 16: 346-354

Fleischer, R., 1952: Radiation integration. Various methods for automatic summing of radiation amts. are discussed. A comparison of automatically recorded daily and hourly amts. of radiation with those values which were obtained with a planimeter showed satisfactory agreement between the re...

Massoud Z.; Gruia M., 1973: Collembola arthropleona from cuba collected from the cuban romanian expedition 1969. Orghidan, T Et Al (Ed ) Resultats Des Expeditions Biospeologiques Cubano-Roumaines A Cuba, No 1 (The Results Of Cubano-Romanian Biospeological Expeditions in Cuba, No 1 ) 424p Illus Maps Editura Academiei Republicii Socialiste Romania: Bucharest, Romania 327-343

Dai, X.; Chang, P.; Zhu, Q.; Liu, W.; Sun, Y.; Zhu, S.; Jiang, Z., 2014: Chitosan oligosaccharides protect rat primary hippocampal neurons from oligomeric β-amyloid 1-42-induced neurotoxicity. β-Amyloid peptide (Aβ), the major component of senile plaques in patients with Alzheimer's disease (AD), is believed to facilitate the progressive neurodegeneration that occurs in this disease. Mounting natural compounds are proved to be po...

Huerta-Riveros, P.C.; Paúl-Espinoza, Ián.R.; Leyton-Pavez, C.E., 2013: The impact of health management indicators on a public health service's strategies. Analysing the impact of health management indicators on a public health service's strategies. Studying a Chilean public healthcare service's strategies (2006-2010) by analysing key management indicators using longitudinal data analysis....

Allwood, G.; Asherson, G.L.; Davey, M.J.; Goodford, P.J., 1971: The early uptake of radioactive calcium by human lymphocytes treated with phytohaemagglutinin. Immunology 21(3): 509-516

Johnson, B.D.; Mather, K.J.; Newcomer, S.C.; Mickleborough, T.D.; Wallace, J.P., 2016: Vitamin C prevents the acute decline of flow-mediated dilation after altered shear rate patterns. Oscillatory and retrograde shear rate (SR) impairs endothelial function, potentially through shear-induced oxidative stress. We tested the hypothesis that acute vitamin C supplementation would prevent the attenuation of brachial artery flow-mediat...

Maier, W., 1944: Bormangel an Weisskohl, Rotkohl, Wirsing, Rosenkohl im Gefassversuch und Freiland. The symptoms of B deficiency in cabbage, red cabbage, savoy and brussels sprouts, as they became manifest in sand and water cultures, are descr. and illustrated in detail. Complete B deficiency in water cultures was remedied by the addition of 1 m...

Karnatz, H., 1970: The tolerance of the herbicide diuron by Golden Delicious apple trees. Diuron was well tolerated by the herbicide-sensitive apple variety Golden Delicious. Growth was increased by about 25% and shoot length by over 30% compared with the untreated control. The percentage of leaves showing yellowing and necrosis rose w...

Wout, J.W. van' t, 1989: Laboratory diagnosis of pneumonia. The laboratory diagnosis of community-acquired pneumonia, hospital acquired pneumonia and pneumonia in the compromised host (including Pneumocystis carinii pneumonia) is discussed. It is concluded that Gram's stain and culture of the sputum a...