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Clinical and economic outcomes of pharmacist-managed aminoglycoside or vancomycin therapy


, : Clinical and economic outcomes of pharmacist-managed aminoglycoside or vancomycin therapy. American Journal of Health-System Pharmacy 62(15): 1596-1605

The associations between pharmacist-managed aminoglycoside or vancomycin therapy for hospitalized Medicare patients who had diagnoses indicating probable treatment with these antibiotics and the major health care outcomes of death rate, length of stay, Medicare charges, hearing loss, and renal impairment were explored. Pharmacist management of drug therapy was evaluated in a study population composed of 199,082 Medicare patients treated in 961 hospitals. In hospitals that did not have pharmacist-managed aminoglycoside or vancomycin therapy, death rates were 6.71% higher (1,048 excess deaths [chi(2) (1) = 43.801, p < 0.0001]), length of stay was 12.28% higher (131,660 excess patient days [U = 4.701 x 10(9), p < 0.0001]), total Medicare charges were 6.30% higher (140,745,924 US dollars in excess total Medicare charges [U = 4.864 x 10(9), p < 0.0001]), drug charges were 8.15% higher (34,769,250 US dollars in excess drug charges [U = 4.785 x 10(9), p < 0.0001]), laboratory charges were 7.80% higher (22,530,474 US dollars in excess laboratory charges [U = 4.860 x 10(9), p < 0.0001]), hearing loss was 46.42% higher (134 more patients with hearing loss [chi(2) = 54.423, df = 1, p < 0.0001]), renal impairment was 33.95% higher (2,801 more patients with renal impairment [chi(2) = 118.13, df = 1, p < 0.0001]), and the death rate in patients who developed complications was 10.15% higher (231 excess deaths [chi(2) = 22.345, df = 1, p < 0.0001]) than in hospitals with pharmacists managing these drugs. The presence of pharmacist-managed aminoglycoside or vancomycin therapy was associated with significant improvement in health care and economic outcomes for Medicare patients who received these drugs.

US$19.90

PMID: 16030370

DOI: 10.2146/ajhp040555


Other references

Sakurai, H.; Kaji, M.; Suemasu, K., 2008: Lipoma of the diaphragm; report of a case. A 50-year-old man was referred to our hospital with an abnormal shadow on chest roentgenogram taken on a health examination in September, 1999. His past history was an operation for scoliosis at the age of 39 years. His family history was unremark...

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Holloway, E.S.; Pilling, R.W.D.; White, R.W., 2010: Endogenous endophthalmitis after methicillin-resistant Staphylococcus aureus sternal wound infection. Endogenous endophthalmitis is an extremely rare but sight-threatening complication of cardiac surgery. A high index of suspicion, prompt diagnosis and treatment, and early involvement of the ophthalmic surgeon is essential. We describe what we bel...

Banerjee, Anirban, 1997: Metabolic salvage strategies against ischemia reperfusion injury. Journal of Molecular & Cellular Cardiology 29(7): A260

Goepfert H., 1973: Notes on the distribution of pileate pore fungi in switzerland. Schweizerische Zeitschrift fuer Pilzkunde 51(2): 17-31

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