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Concurrent chemoradiotherapy for unresectable thymic carcinoma


, : Concurrent chemoradiotherapy for unresectable thymic carcinoma. Chang Gung Medical Journal 27(7): 515-522

Thymic carcinoma is a rare anterior mediastinal neoplasm. It is more invasive and has a poorer prognosis than ordinary thymoma. Complete curative resection is frequently impossible to achieve because of extensive invasion or metastasis at diagnosis. The role of systemic chemotherapy and the optimal regimen in thymic carcinoma remain uncertain. We report our experience with 16 patients with unresectable thymic carcinoma who underwent concurrent chemoradiotherapy. Between July 1989 and July 2003, 29 patients were diagnosed with unresectable thymic carcinoma at our hospital. Sixteen of the 29 patients were treated with concurrent chemoradiotherapy. There were 10 men and 6 women whose ages ranged from 45 to 66 years old. Chemotherapy regimens consisted of either (A) cisplatin plus 5-fluorouracil or (B) doxorubicin, cisplatin, vincristine and cyclophosphamide every 4 weeks for at least 2 cycles. Radiotherapy was given concurrently and ranged from 34.2 to 70 Gy. There were 4 (25.0%) patients with complete responses, 4 (25.0%) with partial responses, 6 (37.5%) with stable disease and 2 (12.5%) with progressive disease. The overall response rate was 50%. The median follow-up was 64 months, and the median survival was 82 months. The overall cumulative survival rates at 1, 2, 3, and 5 years were 93.8%, 81.3%, 74.5%, and 67.7%, respectively. The most common side effects were Grade I/II toxicity, including vomiting, fatigue, and esophagitis. All patients experienced radiation pneumonitis. No life-threatening side effects were noted. Concurrent chemoradiotherapy seems effective for unresectable thymic carcinoma. Our experience, although preliminary, is encouraging and merits conducting a randomized trial to determine the impact of concurrent chemoradiotherapy on unresectable thymic carcinoma.

US$29.90

PMID: 15508874


Other references

Helder-Woolderink, J.M.; Blok, E.A.; Vasen, H.F.A.; Hollema, H.; Mourits, M.J.; D.B.ck, G.H., 2016: Ovarian cancer in Lynch syndrome; a systematic review. The aim was to systematically review the characteristics of ovarian cancer in women with Lynch syndrome (LS) and evaluate the role of surveillance in detection of ovarian cancer in LS. All studies between 1979 and 2015 of women with ovarian cancer...

Schwarz, L.E.; Schlag, P.M., 1999: Molecular biology of breast carcinoma. Current diagnostic, therapeutic and prognostic aspects. There has been a huge progress in our understanding of the genetic mechanisms involved in the development of breast cancer. The clinical consequences are however still small. The most important theoretical models for future clinical investigation,...

Lodi, R.; Todesco, R.; Carini, S., 1984: Preliminary study on the use of lysozyme in Provolone cheese production. In the 1st part of this study, Provolone cheeses were prepared using milk containing lysozyme added at 25 p.p.m.; curd stretching was done manually. The resulting pasta filata and ripening cheeses at 30 and 90 days contained 159, 160 and 169 p.p.m...

Fukazawa S.; Shonai K.; Okamura T.; Takeuchi S., 1984: Insulin hypersecretion by disopyramide in the pancreas islets perifusion in rats. Folia Pharmacologica Japonica 84(5): 127P, 139P

Abdel-Hafez, S.I.I.; Abdel-Kader, M.I.A.; Abdel-Hafez, A.I.I., 1983: Composition of the fungal flora of syrian soils 1. sugar fungi. Fifty-one genera and 146 spp. in addition to 2 varieties of A. nidulans, 1 variety of each of A. flavus and A. terreus were identified from 40 soil samples collected from different places of agricultural soils in Syria on glucose-Czapek's aga...

Little, P.B., 1979: A Malaysian experience with animal disease. Autopsy findings in Malaysian livestock during the year from July 1st, 1976 are analysed. Various parasites were recorded, including Eleophora peoli, Eurytrema pancreaticum, paramphistomes, Fasciola gigantica and Onchocerca armillata in cattle, An...

Gruber, C.L., 1942: Additional ferns in the Kutztown-Fleetwood area. 2 additions to A.F.J. 31: 73. 1941.

Smith, A.M., 1969: Career recruitment of military physicians. Military Medicine 134(7): 528-529

Sekizaki, H.; Itoh, K.; Toyota, E.; Tanizawa, K., 1998: Enzymatic peptide synthesis with p-guanidinophenyl and p-(guanidinomethyl)phenyl esters as acyl donors. Two series of "inverse substrates", N-Boc-amino acid p-guanidinophenyl and p-(guanidinomethyl)phenyl esters, were prepared as acyl donor components for enzymatic peptide synthesis. The kinetic behavior of these esters toward bovine and S...

Green, T.L.; Franz, L.V.; Roffinella, J.P., 1986: Metastatic breast cancer in the maxilla. A case of metastatic breast carcinoma to the maxilla is reported. The lesion was discovered eleven years after initial diagnosis and treatment and was the first indication of metastatic disease.