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Correlations of serous levels of matrix metalloproteinases (MMP-2 and MMP-9) to invasion and metastasis of papillary thyroid carcinoma


, : Correlations of serous levels of matrix metalloproteinases (MMP-2 and MMP-9) to invasion and metastasis of papillary thyroid carcinoma. Ai Zheng 24(6): 740-742

Papillary thyroid carcinoma is a common carcinoma in thyroid without ideal hematological biomarkers to indicate its biological feature. This study was to explore the correlation of serous levels of matrix metalloproteinases (MMP-2 and MMP-9) to invasion and metastasis of papillary thyroid carcinoma. Serous levels of MMP-2 and MMP-9 of 74 patients with pathologically confirmed papillary thyroid carcinoma were measured by zymography. All patients were treated with modified radical operation in the Second Affiliated Hospital of Wenzhou Medical College from 1999 to 2003. Serous levels of activated MMP-2 and MMP-9 were significantly higher in patients with lymph node metastases than in patients without lymph node metastases (71.9+/-11.7 vs. 35.2+/-6.6, P < 0.001; 15.5+/-6.1 vs. 7.3+/-2.3, P < 0.001), and were significantly higher in patients with carcinoma invaded in and through integument than in patients with carcinoma invaded within integument (70.5+/-13.0 vs. 35.4+/-7.9, P < 0.001; 14.7+/-6.1 vs. 8.0+/-4.2, P < 0.001). There was no significant difference in serous levels of activated MMP-2 and MMP-9 between patients with carcinoma diameter of > or =1 cm and < 1 cm (55.4+/-20.4 vs. 59.3+/-20.8, 10.8+/-5.7 vs. 13.7+/-6.8). There was also no significant difference in serous levels of total MMP-2 and MMP-9 between every 2 groups mentioned above (P > 0.05). Serous levels of activated MMP-2 and MMP-9 relate with invasion and metastasis of papillary thyroid carcinoma, but not relate with tumor size.

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PMID: 15946492


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