+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Different patterns of extracellular matrix protein expression in the convexity and the concavity of the dilated aorta with bicuspid aortic valve: preliminary results

, : Different patterns of extracellular matrix protein expression in the convexity and the concavity of the dilated aorta with bicuspid aortic valve: preliminary results. Journal of Thoracic and Cardiovascular Surgery 130(2): 504-511

This study aimed to assess extracellular matrix protein expression patterns at the convexity (right anterolateral wall) and the concavity of the dilated ascending aorta in patients with bicuspid aortic valve disease. Aortic wall specimens were retrieved from the convexity and the concavity in 27 bicuspid aortic valve patients (12 with stenosis and 15 with regurgitation) and 6 heart donors (controls). Morphometry, immunohistochemistry, Western blot, and polymerase chain reaction were performed, focusing on matrix proteins involved in vascular remodeling. Type I and III collagens were significantly decreased in bicuspid-associated dilated aortas versus controls (P < .001), particularly at the convexity (P < .05 vs concavity). Expression of messenger RNA for collagens was lower than normal only in the regurgitant subgroup. At immunohistochemistry, proteins whose overproduction has been demonstrated in response to abnormal wall stress, such as tenascin and fibronectin, were more expressed in the convexity than in the concavity, especially in the stenosis subgroup. Tenascin, which is produced by smooth muscle cells in the synthetic phenotype, was nearly undetectable in controls. Fewer smooth muscle cells (stenosis, P = .017; regurgitation, P = .008) and more severe elastic fiber fragmentation (P = .029 and P < .001) were observed in the convexity versus the concavity. In bicuspid-associated aortic dilations, an asymmetric pattern of matrix protein expression was found that was consistent with the asymmetry in wall-stress distribution reported previously. Differences exist between patients with stenosis and those with regurgitation in terms of protein expression and content in the aortic wall. Further studies could clarify the relations between these findings and the pathogenesis of aortic dilatation in bicuspid aortic valve patients.


PMID: 16077420

DOI: 10.1016/j.jtcvs.2005.01.016

Other references

Loschky, L.C.; Nuthmann, A.; Fortenbaugh, F.C.; Levi, D.M., 2017: Scene perception from central to peripheral vision. Journal of Vision 17(1): 6-6

Basak, C.; Pathak, S.K.mar; Bhattacharyya, A., 2005: NF-kB- and C/EBPb-driven Interleukin-1b Gene Expression and PAK1-mediated Caspase-1 Activation Play Essential Roles in Interleukin-1b Release from Helicobacter pylori Lipopolysaccharide-stimulated Macrophages. The Journal of Biological Chemistry 280(6): 79-88

Crim, G.A., 1993: Effect of aging on microleakage of restorative systems. This study evaluated the sealing properties of AP.H/Prisma Universal Bond 3, Z100/Scotchbond MultiPurpose, AP.H/Imperva Bond, Charisma/Denthesive, Bisfil M/All-Bond 2, resin composite/dentin adhesive systems and Fuji II LC light-cured glass ionome...

Francis, O.H., 1997: Animal husbandry schemes - vast scope on the horizon. An economic status report is given for the dairy, poultry, sheep and goat and pig industries in India (over the period 1994-96). For each industry a profile is given of consumption, production, processing, exports and marketing, in addition to an...

Feaster, F.T., 1995: Refractive surgery knife and process. Official Gazette of the United States Patent & Trademark Office Patents 1179(3): 1661, Oct 17

Koch, A.; Völzke, A.; Puff, B.; Blankenbach, K.; Meyer Z.H.ringdorf, D.; Huwiler, A.; Pfeilschifter, J., 2014: PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells. We previously identified peroxisome proliferator-activated receptor gamma (PPARγ) agonists (thiazolidinediones, TZDs) as modulators of the sphingolipid metabolism in renal mesangial cells. TZDs upregulated sphingosine kinase 1 (SK-1) and increase...

Jonas, J.M.; Pope, H.G.; Hudson, J.I.; Satlin, A., 1984: Undiagnosed vomiting in an older woman: unsuspected bulimia. Bulimia, believed to occur primarily in young women, is rarely suspected in older individuals. The authors report on a 56-year-old woman with rapid cycling bipolar disorder, whose unexplained vomiting proved attributable to bulimia.

Matsui K.; Kato N.; Watanabe N.; Mukoyama M.; Ando K., 1988: Relationships between ataxic manifestation and brain somatostatin levels in ataxic mutant mice. Japanese Journal of Pharmacology 46(SUPPL): 60P

Jaiswal, U.C.; Khanna, A.S., 1995: Culling patterns in different crossbred cattle. Some aspects of culling pattern in different genetic groups of crossbred cattle, viz. 4 halfbreds of Hariana with Holstein-Friesian (FH), Brown Swiss (BH), Jersey (JH) and Red Dane (RH), and 5 three fourths of 2 exotic breeds (FBH, BFH, FJH, JFH a...

Dautrebande, J., 1973: Radiologic studies of the blood vessels. Nursing 45(3): 1-5